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Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry

Raich-Montiu, J ; Krogh, K A ; Granados, M ; Jönsson, Jan Åke LU and Halling-Sorensen, B (2008) In Journal of Chromatography A 1187(1-2). p.275-280
Abstract
A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ivermectin, hollow fibre-supported liquid membrane, LC-MS, surface, water, transformation products
in
Journal of Chromatography A
volume
1187
issue
1-2
pages
275 - 280
publisher
Elsevier
external identifiers
  • wos:000255105300034
  • scopus:40849126494
  • pmid:18329655
ISSN
0021-9673
DOI
10.1016/j.chroma.2008.02.063
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)
id
b6d36e24-3ce0-4c6f-be66-4ac0bf6b25b7 (old id 1205537)
date added to LUP
2016-04-01 12:59:35
date last changed
2020-01-12 10:40:05
@article{b6d36e24-3ce0-4c6f-be66-4ac0bf6b25b7,
  abstract     = {A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimising parameters, such as fibre length, organic solvent, stirring speed, salt level, pH in samples/fibre, extraction time and fibre emptying technique. Method validation with tap and lake water samples provided good linearity and detection limits of 0.2, 1.6 and 0.9 mu g/l for ivermectin, TP1 and TP2 in lake water with RSD below 15%.},
  author       = {Raich-Montiu, J and Krogh, K A and Granados, M and Jönsson, Jan Åke and Halling-Sorensen, B},
  issn         = {0021-9673},
  language     = {eng},
  number       = {1-2},
  pages        = {275--280},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {Determination of ivermectin and transformation products in environmental waters using hollow fibre-supported liquid membrane extraction and liquid chromatography-mass spectrometry/mass spectrometry},
  url          = {http://dx.doi.org/10.1016/j.chroma.2008.02.063},
  doi          = {10.1016/j.chroma.2008.02.063},
  volume       = {1187},
  year         = {2008},
}