Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array-comparative genomic hybridization
Isinger Ekstrand, Anna LU
; Johansson, Jan
LU
; Ohlsson, Mattias
LU
; Francis, Princy
LU
; Staaf, Johan
LU
; Jönsson, Mats
LU
; Borg, Åke
LU
and Nilbert, Mef
LU
(2010)
In Cancer Genetics and Cytogenetics
200(2).
p.120-126
- Abstract
- We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were... (More)
- We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike. (C) 2010 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1629330
- author
- Isinger Ekstrand, Anna
LU
; Johansson, Jan
LU
; Ohlsson, Mattias
LU
; Francis, Princy
LU
; Staaf, Johan
LU
; Jönsson, Mats
LU
; Borg, Åke
LU
and Nilbert, Mef
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Esophageal Neoplasms: genetics, Oligonucleotide Array Sequence Analysis: methods, Comparative Genomic Hybridization: methods, Cyclin-Dependent Kinase 6: genetics, Receptor, Epidermal Growth Factor: genetics, Stomach Neoplasms: genetics
- in
- Cancer Genetics and Cytogenetics
- volume
- 200
- issue
- 2
- pages
- 120 - 126
- publisher
- Elsevier
- external identifiers
-
- wos:000279373500006
- scopus:77953805124
- pmid:20620594
- ISSN
- 0165-4608
- DOI
- 10.1016/j.cancergencyto.2010.03.013
- language
- English
- LU publication?
- yes
- id
- b6fc8bb0-5f9b-42a8-a1ed-b9d72e230798 (old id 1629330)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20620594?dopt=Abstract
- date added to LUP
- 2016-04-01 13:09:59
- date last changed
- 2024-01-09 08:30:28
@article{b6fc8bb0-5f9b-42a8-a1ed-b9d72e230798,
abstract = {{We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike. (C) 2010 Elsevier Inc. All rights reserved.}},
author = {{Isinger Ekstrand, Anna and Johansson, Jan and Ohlsson, Mattias and Francis, Princy and Staaf, Johan and Jönsson, Mats and Borg, Åke and Nilbert, Mef}},
issn = {{0165-4608}},
keywords = {{Esophageal Neoplasms: genetics; Oligonucleotide Array Sequence Analysis: methods; Comparative Genomic Hybridization: methods; Cyclin-Dependent Kinase 6: genetics; Receptor; Epidermal Growth Factor: genetics; Stomach Neoplasms: genetics}},
language = {{eng}},
number = {{2}},
pages = {{120--126}},
publisher = {{Elsevier}},
series = {{Cancer Genetics and Cytogenetics}},
title = {{Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array-comparative genomic hybridization}},
url = {{https://lup.lub.lu.se/search/files/3198945/2375884.pdf}},
doi = {{10.1016/j.cancergencyto.2010.03.013}},
volume = {{200}},
year = {{2010}},
}