Suppression of sensory C fiber-mediated contractions by neuropeptide Y Y1 receptors in the guinea pig bronchi
(1998) In Regulatory Peptides 75-76. p.181-184- Abstract
The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less... (More)
The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less potent than NPY itself and pretreatment with BIBP3226 did not affect the inhibitory response. Human pancreatic polypeptide (Y4-Y6 receptor agonist) was inactive (< or = 1 microM). In conclusion, NPY is capable of suppressing sensory nerve-mediated contractions in the guinea pig bronchi mainly via Y1 receptors.
(Less)
- author
- Grundemar, L LU
- publishing date
- 1998-09-25
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Arginine/analogs & derivatives, Bronchi/drug effects, Bronchoconstriction/drug effects, Guinea Pigs, Humans, In Vitro Techniques, Nerve Fibers/drug effects, Neuropeptide Y/analogs & derivatives, Peptide Fragments/pharmacology, Peptide YY/pharmacology, Receptors, Neuropeptide Y/drug effects
- in
- Regulatory Peptides
- volume
- 75-76
- pages
- 181 - 184
- publisher
- Elsevier
- external identifiers
-
- pmid:9802407
- scopus:4243375137
- ISSN
- 0167-0115
- DOI
- 10.1016/s0167-0115(98)00066-4
- language
- English
- LU publication?
- no
- id
- b701a609-6a75-4d04-b84f-45f79987f82d
- date added to LUP
- 2019-09-03 13:02:41
- date last changed
- 2024-01-01 18:32:29
@article{b701a609-6a75-4d04-b84f-45f79987f82d, abstract = {{<p>The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less potent than NPY itself and pretreatment with BIBP3226 did not affect the inhibitory response. Human pancreatic polypeptide (Y4-Y6 receptor agonist) was inactive (< or = 1 microM). In conclusion, NPY is capable of suppressing sensory nerve-mediated contractions in the guinea pig bronchi mainly via Y1 receptors.</p>}}, author = {{Grundemar, L}}, issn = {{0167-0115}}, keywords = {{Animals; Arginine/analogs & derivatives; Bronchi/drug effects; Bronchoconstriction/drug effects; Guinea Pigs; Humans; In Vitro Techniques; Nerve Fibers/drug effects; Neuropeptide Y/analogs & derivatives; Peptide Fragments/pharmacology; Peptide YY/pharmacology; Receptors, Neuropeptide Y/drug effects}}, language = {{eng}}, month = {{09}}, pages = {{181--184}}, publisher = {{Elsevier}}, series = {{Regulatory Peptides}}, title = {{Suppression of sensory C fiber-mediated contractions by neuropeptide Y Y1 receptors in the guinea pig bronchi}}, url = {{http://dx.doi.org/10.1016/s0167-0115(98)00066-4}}, doi = {{10.1016/s0167-0115(98)00066-4}}, volume = {{75-76}}, year = {{1998}}, }