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Suppression of sensory C fiber-mediated contractions by neuropeptide Y Y1 receptors in the guinea pig bronchi

Grundemar, L LU (1998) In Regulatory Peptides 75-76. p.181-184
Abstract

The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less... (More)

The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less potent than NPY itself and pretreatment with BIBP3226 did not affect the inhibitory response. Human pancreatic polypeptide (Y4-Y6 receptor agonist) was inactive (< or = 1 microM). In conclusion, NPY is capable of suppressing sensory nerve-mediated contractions in the guinea pig bronchi mainly via Y1 receptors.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Arginine/analogs & derivatives, Bronchi/drug effects, Bronchoconstriction/drug effects, Guinea Pigs, Humans, In Vitro Techniques, Nerve Fibers/drug effects, Neuropeptide Y/analogs & derivatives, Peptide Fragments/pharmacology, Peptide YY/pharmacology, Receptors, Neuropeptide Y/drug effects
in
Regulatory Peptides
volume
75-76
pages
181 - 184
publisher
Elsevier
external identifiers
  • pmid:9802407
  • scopus:4243375137
ISSN
0167-0115
DOI
10.1016/s0167-0115(98)00066-4
language
English
LU publication?
no
id
b701a609-6a75-4d04-b84f-45f79987f82d
date added to LUP
2019-09-03 13:02:41
date last changed
2024-01-01 18:32:29
@article{b701a609-6a75-4d04-b84f-45f79987f82d,
  abstract     = {{<p>The aim of the study was to examine which neuropeptide Y (NPY) receptor types that are coupled to inhibition of sensory C fiber-mediated contractions of the guinea pig bronchi. NPY and PYY evoked a concentration-dependent inhibition of the electrically stimulated contractions. The Y1 receptor-selective antagonist BIBP3226 (1 microM) evoked a rightward shift of the NPY-induced response. Also the Y1 (and Y4-Y6) receptor agonist [Leu31,Pro34]NPY suppressed the stimulated contractions with a potency similar to the parent molecule. BIBP3226 (1 microM) also attenuated the response induced by [Leu31,Pro34]NPY. The Y2 receptor agonist [Cys2, Aoc524, D-Cys27]NPY suppressed the stimulated contractions at 1 microM only. NPY 2-36 was much less potent than NPY itself and pretreatment with BIBP3226 did not affect the inhibitory response. Human pancreatic polypeptide (Y4-Y6 receptor agonist) was inactive (&lt; or = 1 microM). In conclusion, NPY is capable of suppressing sensory nerve-mediated contractions in the guinea pig bronchi mainly via Y1 receptors.</p>}},
  author       = {{Grundemar, L}},
  issn         = {{0167-0115}},
  keywords     = {{Animals; Arginine/analogs & derivatives; Bronchi/drug effects; Bronchoconstriction/drug effects; Guinea Pigs; Humans; In Vitro Techniques; Nerve Fibers/drug effects; Neuropeptide Y/analogs & derivatives; Peptide Fragments/pharmacology; Peptide YY/pharmacology; Receptors, Neuropeptide Y/drug effects}},
  language     = {{eng}},
  month        = {{09}},
  pages        = {{181--184}},
  publisher    = {{Elsevier}},
  series       = {{Regulatory Peptides}},
  title        = {{Suppression of sensory C fiber-mediated contractions by neuropeptide Y Y1 receptors in the guinea pig bronchi}},
  url          = {{http://dx.doi.org/10.1016/s0167-0115(98)00066-4}},
  doi          = {{10.1016/s0167-0115(98)00066-4}},
  volume       = {{75-76}},
  year         = {{1998}},
}