What is this condition and how could it be treated?
(2015) In The New Zealand medical journal 128(1420). p.69-69- Abstract
- A 67-year-old, previously fit, woman presented with a history of rectal bleeding.
Per rectum examination revealed a
low rectal mass, which on endoscopy was
demonstrated to be submucosal. MR rectum
confirmed a 5 cm rectal mass displacing the
rectum anteriorly. Chest x-ray and abdominal
CT did not reveal any metastatic disease. Biopsies were consistent with high grade gastrointestinal stromal cell tumour (GIST,) C-Kit was
positive and Ki67 greater >20%. The patient
came forward for an abdominoperineal rectal
resection with permanent stoma and had an
uncomplicated postoperative course.
GISTs are rare tumours that develop from
interstitial cells of Cajal. Only 5% of GIST
tumours arise in... (More) - A 67-year-old, previously fit, woman presented with a history of rectal bleeding.
Per rectum examination revealed a
low rectal mass, which on endoscopy was
demonstrated to be submucosal. MR rectum
confirmed a 5 cm rectal mass displacing the
rectum anteriorly. Chest x-ray and abdominal
CT did not reveal any metastatic disease. Biopsies were consistent with high grade gastrointestinal stromal cell tumour (GIST,) C-Kit was
positive and Ki67 greater >20%. The patient
came forward for an abdominoperineal rectal
resection with permanent stoma and had an
uncomplicated postoperative course.
GISTs are rare tumours that develop from
interstitial cells of Cajal. Only 5% of GIST
tumours arise in the rectum and GIST should
be considered as differential diagnosis for
submucous rectal lesions. Complete resection
is recommended to achieve local disease
control either by local resection or rectal
resection depending on size. The benefit
of imatinib as neoadjuvant treatment is
uncertain. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b73ecc63-6791-4f52-b9d3-dfadb5057dd0
- author
- Buchwald, Pamela LU ; Keller, Eve and Wakeman, Christopher
- publishing date
- 2015-08-21
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Colorectal Neoplasms/diagnosis, Female, Gastrointestinal Stromal Tumors/diagnosis, Humans, Rare Diseases, Treatment Outcome
- in
- The New Zealand medical journal
- volume
- 128
- issue
- 1420
- pages
- 69 - 69
- publisher
- New Zealand Medical Association
- external identifiers
-
- pmid:26367515
- scopus:84940199702
- ISSN
- 0028-8446
- language
- English
- LU publication?
- no
- id
- b73ecc63-6791-4f52-b9d3-dfadb5057dd0
- alternative location
- https://assets-global.website-files.com/5e332a62c703f653182faf47/5e332a62c703f615372fd611_Buchwald-16391420.pdf
- date added to LUP
- 2021-12-29 12:33:28
- date last changed
- 2024-01-05 23:15:40
@article{b73ecc63-6791-4f52-b9d3-dfadb5057dd0, abstract = {{A 67-year-old, previously fit, woman presented with a history of rectal bleeding.<br/>Per rectum examination revealed a<br/>low rectal mass, which on endoscopy was<br/>demonstrated to be submucosal. MR rectum<br/>confirmed a 5 cm rectal mass displacing the<br/>rectum anteriorly. Chest x-ray and abdominal<br/>CT did not reveal any metastatic disease. Biopsies were consistent with high grade gastrointestinal stromal cell tumour (GIST,) C-Kit was<br/>positive and Ki67 greater >20%. The patient<br/>came forward for an abdominoperineal rectal<br/>resection with permanent stoma and had an<br/>uncomplicated postoperative course.<br/>GISTs are rare tumours that develop from<br/>interstitial cells of Cajal. Only 5% of GIST<br/>tumours arise in the rectum and GIST should<br/>be considered as differential diagnosis for<br/>submucous rectal lesions. Complete resection<br/>is recommended to achieve local disease<br/>control either by local resection or rectal<br/>resection depending on size. The benefit<br/>of imatinib as neoadjuvant treatment is<br/>uncertain.}}, author = {{Buchwald, Pamela and Keller, Eve and Wakeman, Christopher}}, issn = {{0028-8446}}, keywords = {{Aged; Colorectal Neoplasms/diagnosis; Female; Gastrointestinal Stromal Tumors/diagnosis; Humans; Rare Diseases; Treatment Outcome}}, language = {{eng}}, month = {{08}}, number = {{1420}}, pages = {{69--69}}, publisher = {{New Zealand Medical Association}}, series = {{The New Zealand medical journal}}, title = {{What is this condition and how could it be treated?}}, url = {{https://assets-global.website-files.com/5e332a62c703f653182faf47/5e332a62c703f615372fd611_Buchwald-16391420.pdf}}, volume = {{128}}, year = {{2015}}, }