Effects of gastrin on calcium homeostasis in chickens
Persson, Per ; Gagnemo Persson, Rebecca LU
; Örberg, Jan
; Chen, Duan
and Håkanson, Rolf
LU
(1991)
In Endocrinology
129(3).
p.1162-1166
- Abstract
- As in the rat, gastrin and an extract of the acid-producing part of the stomach (proventriculus) were found to lower the blood Ca2+ concentration in the chicken. Furthermore, gastrin enhanced the uptake of 45Ca into the femur. It has been suggested previously that gastrin causes hypocalcemia in the rat by releasing gastrocalcin, a hypothetical hormone thought to reside in the acid-producing part of the stomach. The results of the present study in the chicken are in agreement with this concept. Not only exogenous, but also endogenous gastrin lowered blood calcium levels. Thus, the serum gastrin concentration was increased in response to ranitidine-evoked blockade of the gastric acid output; the rise in gastrin was associated with a... (More)
- As in the rat, gastrin and an extract of the acid-producing part of the stomach (proventriculus) were found to lower the blood Ca2+ concentration in the chicken. Furthermore, gastrin enhanced the uptake of 45Ca into the femur. It has been suggested previously that gastrin causes hypocalcemia in the rat by releasing gastrocalcin, a hypothetical hormone thought to reside in the acid-producing part of the stomach. The results of the present study in the chicken are in agreement with this concept. Not only exogenous, but also endogenous gastrin lowered blood calcium levels. Thus, the serum gastrin concentration was increased in response to ranitidine-evoked blockade of the gastric acid output; the rise in gastrin was associated with a transient drop in blood calcium. Also, food intake produced a rise in the serum gastrin concentration and a transient drop in blood calcium. However, injection of ranitidine or food intake in proventriclectomized (acid-producing part of the stomach extirpated) chickens failed to lower blood calcium, supporting the view that the gastrin-evoked hypocalcemia depends upon an agent in the gastric (proventriculus) mucosa. We suggest that endogenous and exogenous gastrin evoke hypocalcemia in the chicken by the same mechanism as that which has been postulated in the rat, i.e. by mobilization of the candidate hormone gastrocalcin from endocrine cells in the acid-producing gastric mucosa. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b75a4f7b-3cf0-40f0-9c5b-c6925a1a58bd
- author
- Persson, Per
; Gagnemo Persson, Rebecca
LU
; Örberg, Jan
; Chen, Duan
and Håkanson, Rolf
LU
- organization
- publishing date
- 1991-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Endocrinology
- volume
- 129
- issue
- 3
- pages
- 5 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:0025991825
- pmid:1874162
- ISSN
- 0013-7227
- DOI
- 10.1210/endo-129-3-1162
- language
- English
- LU publication?
- yes
- id
- b75a4f7b-3cf0-40f0-9c5b-c6925a1a58bd
- date added to LUP
- 2016-08-19 13:24:08
- date last changed
- 2021-01-03 10:53:08
@article{b75a4f7b-3cf0-40f0-9c5b-c6925a1a58bd,
abstract = {{As in the rat, gastrin and an extract of the acid-producing part of the stomach (proventriculus) were found to lower the blood Ca2+ concentration in the chicken. Furthermore, gastrin enhanced the uptake of 45Ca into the femur. It has been suggested previously that gastrin causes hypocalcemia in the rat by releasing gastrocalcin, a hypothetical hormone thought to reside in the acid-producing part of the stomach. The results of the present study in the chicken are in agreement with this concept. Not only exogenous, but also endogenous gastrin lowered blood calcium levels. Thus, the serum gastrin concentration was increased in response to ranitidine-evoked blockade of the gastric acid output; the rise in gastrin was associated with a transient drop in blood calcium. Also, food intake produced a rise in the serum gastrin concentration and a transient drop in blood calcium. However, injection of ranitidine or food intake in proventriclectomized (acid-producing part of the stomach extirpated) chickens failed to lower blood calcium, supporting the view that the gastrin-evoked hypocalcemia depends upon an agent in the gastric (proventriculus) mucosa. We suggest that endogenous and exogenous gastrin evoke hypocalcemia in the chicken by the same mechanism as that which has been postulated in the rat, i.e. by mobilization of the candidate hormone gastrocalcin from endocrine cells in the acid-producing gastric mucosa.}},
author = {{Persson, Per and Gagnemo Persson, Rebecca and Örberg, Jan and Chen, Duan and Håkanson, Rolf}},
issn = {{0013-7227}},
language = {{eng}},
number = {{3}},
pages = {{1162--1166}},
publisher = {{Oxford University Press}},
series = {{Endocrinology}},
title = {{Effects of gastrin on calcium homeostasis in chickens}},
url = {{http://dx.doi.org/10.1210/endo-129-3-1162}},
doi = {{10.1210/endo-129-3-1162}},
volume = {{129}},
year = {{1991}},
}