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Sexual dimorphism in transmission of expression of islet autoantibodies to offspring

Yu, L.; Chase, H. P.; Falorni, A.; Rewers, M.; Lernmark, Å LU and Eisenbarth, G. S. (1995) In Diabetologia 38(11). p.1353-1357
Abstract

To help elucidate the mode of inheritance of insulin-dependent diabetes mellitus (IDDM), we measured GAD (glutamic acid decarboxylase) autoantibodies (GAD65Ab), insulin autoantibodies (IAA), and cytoplasmic islet cell autoantibodies (ICA) in 292 sequentially screened non-diabetic offspring of patients with IDDM. The prevalence of these islet autoantibodies was higher in offspring of diabetic fathers than in offspring of diabetic mothers. The prevalences of GAD65Ab, IAA, and ICA in the offspring of diabetic fathers were 11.5%, 10.8%, and 8.1% vs 2.1%, 1.4%, and 2.8%, respectively in the offspring of diabetic mothers (p<0.002, p<0.001, and p=0.06 NS). Amongst autoantibody-positive relatives the IAA and ICA levels were significantly... (More)

To help elucidate the mode of inheritance of insulin-dependent diabetes mellitus (IDDM), we measured GAD (glutamic acid decarboxylase) autoantibodies (GAD65Ab), insulin autoantibodies (IAA), and cytoplasmic islet cell autoantibodies (ICA) in 292 sequentially screened non-diabetic offspring of patients with IDDM. The prevalence of these islet autoantibodies was higher in offspring of diabetic fathers than in offspring of diabetic mothers. The prevalences of GAD65Ab, IAA, and ICA in the offspring of diabetic fathers were 11.5%, 10.8%, and 8.1% vs 2.1%, 1.4%, and 2.8%, respectively in the offspring of diabetic mothers (p<0.002, p<0.001, and p=0.06 NS). Amongst autoantibody-positive relatives the IAA and ICA levels were significantly higher in offspring of diabetic fathers than of diabetic mothers (p<0.002 and p<0.01, respectively). The frequencies of these autoantibodies were equal in male and female offspring. We conclude that IDDM mothers transmitted islet autoimmunity less frequently to their offspring than IDDM fathers. Given the markedly lower frequency of autoantibodies in offspring of mothers, larger sample sizes will be required to determine whether islet autoantibodies are influenced by age of IDDM onset of mothers, maternal age of pregnancy, and presence of diabetes in these mothers prior to conception.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
autoimmunity, Islet autoantibodies, offspring, transmission
in
Diabetologia
volume
38
issue
11
pages
1353 - 1357
publisher
Springer
external identifiers
  • scopus:0028882604
ISSN
0012-186X
DOI
10.1007/BF00401769
language
English
LU publication?
no
id
b7981146-af4d-4994-9e11-709f5759bdbf
date added to LUP
2019-09-11 09:01:18
date last changed
2019-09-30 15:57:02
@article{b7981146-af4d-4994-9e11-709f5759bdbf,
  abstract     = {<p>To help elucidate the mode of inheritance of insulin-dependent diabetes mellitus (IDDM), we measured GAD (glutamic acid decarboxylase) autoantibodies (GAD65Ab), insulin autoantibodies (IAA), and cytoplasmic islet cell autoantibodies (ICA) in 292 sequentially screened non-diabetic offspring of patients with IDDM. The prevalence of these islet autoantibodies was higher in offspring of diabetic fathers than in offspring of diabetic mothers. The prevalences of GAD65Ab, IAA, and ICA in the offspring of diabetic fathers were 11.5%, 10.8%, and 8.1% vs 2.1%, 1.4%, and 2.8%, respectively in the offspring of diabetic mothers (p&lt;0.002, p&lt;0.001, and p=0.06 NS). Amongst autoantibody-positive relatives the IAA and ICA levels were significantly higher in offspring of diabetic fathers than of diabetic mothers (p&lt;0.002 and p&lt;0.01, respectively). The frequencies of these autoantibodies were equal in male and female offspring. We conclude that IDDM mothers transmitted islet autoimmunity less frequently to their offspring than IDDM fathers. Given the markedly lower frequency of autoantibodies in offspring of mothers, larger sample sizes will be required to determine whether islet autoantibodies are influenced by age of IDDM onset of mothers, maternal age of pregnancy, and presence of diabetes in these mothers prior to conception.</p>},
  author       = {Yu, L. and Chase, H. P. and Falorni, A. and Rewers, M. and Lernmark, Å and Eisenbarth, G. S.},
  issn         = {0012-186X},
  keyword      = {autoimmunity,Islet autoantibodies,offspring,transmission},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {1353--1357},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Sexual dimorphism in transmission of expression of islet autoantibodies to offspring},
  url          = {http://dx.doi.org/10.1007/BF00401769},
  volume       = {38},
  year         = {1995},
}