A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat
Bruschettini, Matteo LU
; van den Hove, DLA
; Gazzolo, D
; Bruschettini, P
; Blanco, CE
and Steinbusch, HWM
(2005)
In Developmental Brain Research
159(2).
p.113-118
- Abstract
- The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of... (More)
- The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of betamethasone decreased S100B concentration in the serum of males at P1, whereas in the hippocampus, it was reduced by the clinically-equivalent dose only. This suggests that lowering the dose of antenatal betamethasone may be less detrimental for brain maturation and therefore we reiterate the need for clinical trials with a low dose regimen. (c) 2005 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856253
- author
- Bruschettini, Matteo
LU
; van den Hove, DLA
; Gazzolo, D
; Bruschettini, P
; Blanco, CE
and Steinbusch, HWM
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glucocorticoid, corticosteroid, prenatal, steroid, side-effect, brain development
- in
- Developmental Brain Research
- volume
- 159
- issue
- 2
- pages
- 113 - 118
- publisher
- Elsevier
- external identifiers
-
- wos:000232524900004
- scopus:25144514584
- ISSN
- 0165-3806
- DOI
- 10.1016/j.devbrainres.2005.07.003
- language
- English
- LU publication?
- no
- id
- b7a9ea5e-2713-4a4e-b80c-6490b66994d0 (old id 7856253)
- date added to LUP
- 2016-04-01 17:07:27
- date last changed
- 2022-04-23 02:53:23
@article{b7a9ea5e-2713-4a4e-b80c-6490b66994d0,
abstract = {{The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of betamethasone decreased S100B concentration in the serum of males at P1, whereas in the hippocampus, it was reduced by the clinically-equivalent dose only. This suggests that lowering the dose of antenatal betamethasone may be less detrimental for brain maturation and therefore we reiterate the need for clinical trials with a low dose regimen. (c) 2005 Elsevier B.V. All rights reserved.}},
author = {{Bruschettini, Matteo and van den Hove, DLA and Gazzolo, D and Bruschettini, P and Blanco, CE and Steinbusch, HWM}},
issn = {{0165-3806}},
keywords = {{glucocorticoid; corticosteroid; prenatal; steroid; side-effect; brain development}},
language = {{eng}},
number = {{2}},
pages = {{113--118}},
publisher = {{Elsevier}},
series = {{Developmental Brain Research}},
title = {{A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat}},
url = {{http://dx.doi.org/10.1016/j.devbrainres.2005.07.003}},
doi = {{10.1016/j.devbrainres.2005.07.003}},
volume = {{159}},
year = {{2005}},
}