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Cellular immune dysfunction in immune thrombocytopenia (ITP)

McKenzie, Christopher G J ; Guo, Li LU ; Freedman, John and Semple, John W LU (2013) In British Journal of Haematology 163(1). p.10-23
Abstract

Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP... (More)

Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP pathophysiology: APC, T cells and B cells, and will review how they interact with each other to initiate and perpetuate ITP, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of ITP.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antigen-Presenting Cells, B-Lymphocytes, Disease Models, Animal, Humans, Immunity, Cellular, Purpura, Thrombocytopenic, Idiopathic, Signal Transduction, T-Lymphocyte Subsets, Journal Article, Research Support, Non-U.S. Gov't, Review
in
British Journal of Haematology
volume
163
issue
1
pages
14 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84884152225
  • pmid:23937260
ISSN
0007-1048
DOI
10.1111/bjh.12480
language
English
LU publication?
no
id
b7dd97c9-3748-4715-8123-a000a35b6095
date added to LUP
2016-09-23 12:01:49
date last changed
2024-12-28 11:30:25
@article{b7dd97c9-3748-4715-8123-a000a35b6095,
  abstract     = {{<p>Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP pathophysiology: APC, T cells and B cells, and will review how they interact with each other to initiate and perpetuate ITP, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of ITP.</p>}},
  author       = {{McKenzie, Christopher G J and Guo, Li and Freedman, John and Semple, John W}},
  issn         = {{0007-1048}},
  keywords     = {{Animals; Antigen-Presenting Cells; B-Lymphocytes; Disease Models, Animal; Humans; Immunity, Cellular; Purpura, Thrombocytopenic, Idiopathic; Signal Transduction; T-Lymphocyte Subsets; Journal Article; Research Support, Non-U.S. Gov't; Review}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{10--23}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{Cellular immune dysfunction in immune thrombocytopenia (ITP)}},
  url          = {{http://dx.doi.org/10.1111/bjh.12480}},
  doi          = {{10.1111/bjh.12480}},
  volume       = {{163}},
  year         = {{2013}},
}