Model for melting of confined DNA
(2015) In Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) 91(6).- Abstract
- When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo... (More)
- When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo simulations we then show that a model incorporating self-avoidance shows qualitatively the same behavior and that the effect of confinement is stronger than in the ideal case. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7587785
- author
- Werner, E. ; Reiter-Schad, Michaela LU ; Ambjörnsson, Tobias LU and Mehlig, B.
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
- volume
- 91
- issue
- 6
- article number
- 060702
- publisher
- American Physical Society
- external identifiers
-
- wos:000356929400002
- pmid:26172649
- scopus:84937019974
- pmid:26172649
- ISSN
- 1539-3755
- DOI
- 10.1103/PhysRevE.91.060702
- language
- English
- LU publication?
- yes
- id
- b7f0e4b2-d31b-4095-b634-dacba8195c33 (old id 7587785)
- date added to LUP
- 2016-04-01 10:39:16
- date last changed
- 2024-02-05 10:14:40
@article{b7f0e4b2-d31b-4095-b634-dacba8195c33,
abstract = {{When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo simulations we then show that a model incorporating self-avoidance shows qualitatively the same behavior and that the effect of confinement is stronger than in the ideal case.}},
author = {{Werner, E. and Reiter-Schad, Michaela and Ambjörnsson, Tobias and Mehlig, B.}},
issn = {{1539-3755}},
language = {{eng}},
number = {{6}},
publisher = {{American Physical Society}},
series = {{Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)}},
title = {{Model for melting of confined DNA}},
url = {{http://dx.doi.org/10.1103/PhysRevE.91.060702}},
doi = {{10.1103/PhysRevE.91.060702}},
volume = {{91}},
year = {{2015}},
}