Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives : With Relevance for Fragrance Synthesis
(2018) In Journal of Organic Chemistry 83(18). p.10864-10870- Abstract
A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b8051eaf-ea10-48a7-a814-8b363e4f2bc3
- author
- Manojveer, Seetharaman LU ; Salahi, Saleh LU ; Wendt, Ola F. LU and Johnson, Magnus T. LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Organic Chemistry
- volume
- 83
- issue
- 18
- pages
- 7 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:30091596
- scopus:85052320561
- ISSN
- 0022-3263
- DOI
- 10.1021/acs.joc.8b01558
- language
- English
- LU publication?
- yes
- id
- b8051eaf-ea10-48a7-a814-8b363e4f2bc3
- date added to LUP
- 2020-04-23 10:23:39
- date last changed
- 2024-08-07 18:29:48
@article{b8051eaf-ea10-48a7-a814-8b363e4f2bc3, abstract = {{<p>A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl<sub>2</sub>(PPh<sub>3</sub>)<sub>3</sub> as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.</p>}}, author = {{Manojveer, Seetharaman and Salahi, Saleh and Wendt, Ola F. and Johnson, Magnus T.}}, issn = {{0022-3263}}, language = {{eng}}, number = {{18}}, pages = {{10864--10870}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of Organic Chemistry}}, title = {{Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives : With Relevance for Fragrance Synthesis}}, url = {{http://dx.doi.org/10.1021/acs.joc.8b01558}}, doi = {{10.1021/acs.joc.8b01558}}, volume = {{83}}, year = {{2018}}, }