The use of carvone in consecutive patch testing
(2023) In Contact Dermatitis 88(3). p.206-211- Abstract
Background: Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions. Objectives: To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population. Method: A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database. Results: Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of... (More)
Background: Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions. Objectives: To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population. Method: A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database. Results: Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy. Conclusions: The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.
(Less)
- author
- Enberg, Johanna ; Hamnerius, Nils LU ; Kroona, Liv and Svedman, Cecilia LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- contact allergy, fragrances, l-carvone, oral lichen, patch test
- in
- Contact Dermatitis
- volume
- 88
- issue
- 3
- pages
- 206 - 211
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:36399045
- scopus:85142636048
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.14249
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
- id
- b80fe399-8abc-4c13-b391-87fc00fbbb4f
- date added to LUP
- 2023-01-25 10:59:35
- date last changed
- 2024-04-18 08:42:10
@article{b80fe399-8abc-4c13-b391-87fc00fbbb4f,
abstract = {{<p>Background: Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions. Objectives: To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population. Method: A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database. Results: Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy. Conclusions: The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.</p>}},
author = {{Enberg, Johanna and Hamnerius, Nils and Kroona, Liv and Svedman, Cecilia}},
issn = {{0105-1873}},
keywords = {{contact allergy; fragrances; l-carvone; oral lichen; patch test}},
language = {{eng}},
number = {{3}},
pages = {{206--211}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{The use of carvone in consecutive patch testing}},
url = {{http://dx.doi.org/10.1111/cod.14249}},
doi = {{10.1111/cod.14249}},
volume = {{88}},
year = {{2023}},
}