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Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons

Brundin, P LU ; Nilsson, O G LU ; Gage, F H and Björklund, A LU orcid (1985) In Experimental Brain Research 60(1). p.8-204
Abstract

The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft... (More)

The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.

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author
; ; and
organization
publishing date
type
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publication status
published
subject
keywords
Animals, Cyclosporins/pharmacology, Dopamine/physiology, Female, Graft Survival/drug effects, Hydroxydopamines, Mesencephalon/transplantation, Mice, Mice, Inbred A, Oxidopamine, Parkinson Disease, Secondary/chemically induced, Rats, Rats, Inbred Strains, Transplantation, Heterologous
in
Experimental Brain Research
volume
60
issue
1
pages
5 pages
publisher
Springer
external identifiers
  • scopus:0022239947
  • pmid:3930278
ISSN
0014-4819
DOI
10.1007/BF00237035
language
English
LU publication?
yes
id
b81f6187-cd20-454c-858f-27f6231fed15
date added to LUP
2019-06-25 10:26:56
date last changed
2024-01-01 13:04:47
@article{b81f6187-cd20-454c-858f-27f6231fed15,
  abstract     = {{<p>The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.</p>}},
  author       = {{Brundin, P and Nilsson, O G and Gage, F H and Björklund, A}},
  issn         = {{0014-4819}},
  keywords     = {{Animals; Cyclosporins/pharmacology; Dopamine/physiology; Female; Graft Survival/drug effects; Hydroxydopamines; Mesencephalon/transplantation; Mice; Mice, Inbred A; Oxidopamine; Parkinson Disease, Secondary/chemically induced; Rats; Rats, Inbred Strains; Transplantation, Heterologous}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{8--204}},
  publisher    = {{Springer}},
  series       = {{Experimental Brain Research}},
  title        = {{Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons}},
  url          = {{http://dx.doi.org/10.1007/BF00237035}},
  doi          = {{10.1007/BF00237035}},
  volume       = {{60}},
  year         = {{1985}},
}