Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons
(1985) In Experimental Brain Research 60(1). p.8-204- Abstract
The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft... (More)
The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.
(Less)
- author
- Brundin, P LU ; Nilsson, O G LU ; Gage, F H and Björklund, A LU
- organization
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Cyclosporins/pharmacology, Dopamine/physiology, Female, Graft Survival/drug effects, Hydroxydopamines, Mesencephalon/transplantation, Mice, Mice, Inbred A, Oxidopamine, Parkinson Disease, Secondary/chemically induced, Rats, Rats, Inbred Strains, Transplantation, Heterologous
- in
- Experimental Brain Research
- volume
- 60
- issue
- 1
- pages
- 5 pages
- publisher
- Springer
- external identifiers
-
- scopus:0022239947
- pmid:3930278
- ISSN
- 0014-4819
- DOI
- 10.1007/BF00237035
- language
- English
- LU publication?
- yes
- id
- b81f6187-cd20-454c-858f-27f6231fed15
- date added to LUP
- 2019-06-25 10:26:56
- date last changed
- 2024-01-01 13:04:47
@article{b81f6187-cd20-454c-858f-27f6231fed15, abstract = {{<p>The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.</p>}}, author = {{Brundin, P and Nilsson, O G and Gage, F H and Björklund, A}}, issn = {{0014-4819}}, keywords = {{Animals; Cyclosporins/pharmacology; Dopamine/physiology; Female; Graft Survival/drug effects; Hydroxydopamines; Mesencephalon/transplantation; Mice; Mice, Inbred A; Oxidopamine; Parkinson Disease, Secondary/chemically induced; Rats; Rats, Inbred Strains; Transplantation, Heterologous}}, language = {{eng}}, number = {{1}}, pages = {{8--204}}, publisher = {{Springer}}, series = {{Experimental Brain Research}}, title = {{Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons}}, url = {{http://dx.doi.org/10.1007/BF00237035}}, doi = {{10.1007/BF00237035}}, volume = {{60}}, year = {{1985}}, }