Focal EEG findings in juvenile absence syndrome and the effect of antiepileptic drugs
Irsel Tezer, F. ; Sahin, Gurdal LU
; Ciger, Abdurrahman
and Saygi, Serap
(2008)
In Clinical EEG and Neuroscience
39(1).
p.33-38
- Abstract
The presence of focal EEG abnormalities in juvenile absence syndrome (JAS) may cause it to be misdiagnosed as focal epilepsy. The purpose of our study was to determine the presence of focal EEG abnormalities in patients with JAS and to ascertain whether some clinical features or antiepileptic drugs (AEDs) have an effect on focality. Serial EEGs of 52 consecutive patients with JAS were retrospectively analyzed. The patients were divided into two groups according to whether they were treated with valproic acid and/or lamotrigine (VA-LTG) or not during the times of these EEG recordings. The relationship between the presence of EEG focality and the use of AEDs in addition to other risk factors was examined. Two or three consecutive EEGs... (More)
The presence of focal EEG abnormalities in juvenile absence syndrome (JAS) may cause it to be misdiagnosed as focal epilepsy. The purpose of our study was to determine the presence of focal EEG abnormalities in patients with JAS and to ascertain whether some clinical features or antiepileptic drugs (AEDs) have an effect on focality. Serial EEGs of 52 consecutive patients with JAS were retrospectively analyzed. The patients were divided into two groups according to whether they were treated with valproic acid and/or lamotrigine (VA-LTG) or not during the times of these EEG recordings. The relationship between the presence of EEG focality and the use of AEDs in addition to other risk factors was examined. Two or three consecutive EEGs (total 100) of the 52 patients were evaluated. Among these, the rates of focal EEG abnormalities were 18%, 36%, and 25% during the follow-up EEGs without AEDs (5/27) and first (16/45) and second EEGs (7/28) with AEDs, respectively. The last two EEGs showed a tendency towards a higher proportion of EEG focality in patients who received other AEDs (47%-45%) compared with those that received VA-LTG (13%-12%). The proportion of JAS patients with focal EEG findings in serial EEGs tended to decrease with an increasing rate of VA-LTG use. As a hypothetical explanation, changes in EEG focality may reflect the effect of AEDs other than VA and/or LTG, in addition to a developing hyperexcitable cortical area.
(Less)
- author
- Irsel Tezer, F.
; Sahin, Gurdal
LU
; Ciger, Abdurrahman
and Saygi, Serap
- publishing date
- 2008-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antiepileptic drugs, Electroencephalography, Focal EEG findings, Juvenile absence epilepsy, Juvenile absence syndrome
- in
- Clinical EEG and Neuroscience
- volume
- 39
- issue
- 1
- pages
- 6 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:18318417
- scopus:40949127367
- ISSN
- 1550-0594
- DOI
- 10.1177/155005940803900111
- language
- English
- LU publication?
- no
- id
- b821f6d2-84b3-400d-ae68-21e2bda8adf6
- date added to LUP
- 2019-06-14 19:58:32
- date last changed
- 2024-01-01 10:41:56
@article{b821f6d2-84b3-400d-ae68-21e2bda8adf6,
abstract = {{<p>The presence of focal EEG abnormalities in juvenile absence syndrome (JAS) may cause it to be misdiagnosed as focal epilepsy. The purpose of our study was to determine the presence of focal EEG abnormalities in patients with JAS and to ascertain whether some clinical features or antiepileptic drugs (AEDs) have an effect on focality. Serial EEGs of 52 consecutive patients with JAS were retrospectively analyzed. The patients were divided into two groups according to whether they were treated with valproic acid and/or lamotrigine (VA-LTG) or not during the times of these EEG recordings. The relationship between the presence of EEG focality and the use of AEDs in addition to other risk factors was examined. Two or three consecutive EEGs (total 100) of the 52 patients were evaluated. Among these, the rates of focal EEG abnormalities were 18%, 36%, and 25% during the follow-up EEGs without AEDs (5/27) and first (16/45) and second EEGs (7/28) with AEDs, respectively. The last two EEGs showed a tendency towards a higher proportion of EEG focality in patients who received other AEDs (47%-45%) compared with those that received VA-LTG (13%-12%). The proportion of JAS patients with focal EEG findings in serial EEGs tended to decrease with an increasing rate of VA-LTG use. As a hypothetical explanation, changes in EEG focality may reflect the effect of AEDs other than VA and/or LTG, in addition to a developing hyperexcitable cortical area.</p>}},
author = {{Irsel Tezer, F. and Sahin, Gurdal and Ciger, Abdurrahman and Saygi, Serap}},
issn = {{1550-0594}},
keywords = {{Antiepileptic drugs; Electroencephalography; Focal EEG findings; Juvenile absence epilepsy; Juvenile absence syndrome}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{33--38}},
publisher = {{SAGE Publications}},
series = {{Clinical EEG and Neuroscience}},
title = {{Focal EEG findings in juvenile absence syndrome and the effect of antiepileptic drugs}},
url = {{http://dx.doi.org/10.1177/155005940803900111}},
doi = {{10.1177/155005940803900111}},
volume = {{39}},
year = {{2008}},
}