A C-H Activation Approach to the Tricyclic Core of Glionitrin A and B
(2022) In ACS Omega 7(14). p.12329-12341- Abstract
Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at elaborating the tricyclic structures into the corresponding natural products is discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b859a9dc-1a49-458f-9b7d-550d308cd940
- author
- Koning, Nicolas R. LU and Strand, Daniel LU
- organization
- publishing date
- 2022-04-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ACS Omega
- volume
- 7
- issue
- 14
- pages
- 12329 - 12341
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:35449932
- scopus:85128286008
- ISSN
- 2470-1343
- DOI
- 10.1021/acsomega.2c00810
- language
- English
- LU publication?
- yes
- id
- b859a9dc-1a49-458f-9b7d-550d308cd940
- date added to LUP
- 2022-06-20 16:21:14
- date last changed
- 2024-06-11 00:56:43
@article{b859a9dc-1a49-458f-9b7d-550d308cd940, abstract = {{<p>Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at elaborating the tricyclic structures into the corresponding natural products is discussed. </p>}}, author = {{Koning, Nicolas R. and Strand, Daniel}}, issn = {{2470-1343}}, language = {{eng}}, month = {{04}}, number = {{14}}, pages = {{12329--12341}}, publisher = {{The American Chemical Society (ACS)}}, series = {{ACS Omega}}, title = {{A C-H Activation Approach to the Tricyclic Core of Glionitrin A and B}}, url = {{http://dx.doi.org/10.1021/acsomega.2c00810}}, doi = {{10.1021/acsomega.2c00810}}, volume = {{7}}, year = {{2022}}, }