Breathlessness dimensions should be evaluated in relation to the level of exertion : A clinical study
(2025) In Respiratory Physiology and Neurobiology 333.- Abstract
Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of outpatients aged ≥ 18 years performing a symptom-limited cycle incremental exercise test (IET). Breathlessness sensations at end of IET were identified using the multidimensional dyspnea profile (MDP) 30-min post-exercise and compared between people with abnormally high breathlessness (Borg 0–10 rating > upper limit of normal [ULN]) and people... (More)
Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of outpatients aged ≥ 18 years performing a symptom-limited cycle incremental exercise test (IET). Breathlessness sensations at end of IET were identified using the multidimensional dyspnea profile (MDP) 30-min post-exercise and compared between people with abnormally high breathlessness (Borg 0–10 rating > upper limit of normal [ULN]) and people within normal ranges (≤ ULN) in relation to the percentage of predicted peak power output defined by normative reference equations. Results: Of 92 participants, 20 (22 %) had abnormally high breathlessness. Compared with those with normal breathlessness (n = 72 [78 %]), the abnormal group reported higher symptom intensity at peak exercise (7.9 ± 1.7 vs 6.3 ± 1.4 Borg units; p < 0.001) and had lower peak power output 129 ± 52 W vs 167 ± 55 W; p < 0.001). Differences between those with normal, and abnormal exertional breathlessness regarding MDP ratings were not statistically significant (all p > 0.05): overall unpleasantness, 4.1 ± 2.3 vs 4.7 ± 1.6; immediate perception, 10.9 ± 2.8 vs 11.5 ± 1.8; and emotional response, 4.1 ± 7.6 vs 3.2 ± 7.5. MDP ratings had no relation to peak power output. Conclusion: Breathlessness dimensions are similar at the peak of a standardized IET and cannot differentiate between people with normal and abnormally high exertional breathlessness.
(Less)
- author
- Elmberg, Viktor
LU
; Ali, Gufran ; Gustafsson, David LU
; Jensen, Dennis and Ekström, Magnus LU
- organization
- publishing date
- 2025-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breathlessness, Dyspnea, Exercise testing, MDP, Multiple dyspnoea profile
- in
- Respiratory Physiology and Neurobiology
- volume
- 333
- article number
- 104398
- publisher
- Elsevier
- external identifiers
-
- pmid:39870285
- scopus:85216311968
- ISSN
- 1569-9048
- DOI
- 10.1016/j.resp.2025.104398
- language
- English
- LU publication?
- yes
- id
- b88c2834-fcbb-40a3-9381-0899455941c2
- date added to LUP
- 2025-03-20 14:39:46
- date last changed
- 2025-07-10 23:22:47
@article{b88c2834-fcbb-40a3-9381-0899455941c2, abstract = {{<p>Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of outpatients aged ≥ 18 years performing a symptom-limited cycle incremental exercise test (IET). Breathlessness sensations at end of IET were identified using the multidimensional dyspnea profile (MDP) 30-min post-exercise and compared between people with abnormally high breathlessness (Borg 0–10 rating > upper limit of normal [ULN]) and people within normal ranges (≤ ULN) in relation to the percentage of predicted peak power output defined by normative reference equations. Results: Of 92 participants, 20 (22 %) had abnormally high breathlessness. Compared with those with normal breathlessness (n = 72 [78 %]), the abnormal group reported higher symptom intensity at peak exercise (7.9 ± 1.7 vs 6.3 ± 1.4 Borg units; p < 0.001) and had lower peak power output 129 ± 52 W vs 167 ± 55 W; p < 0.001). Differences between those with normal, and abnormal exertional breathlessness regarding MDP ratings were not statistically significant (all p > 0.05): overall unpleasantness, 4.1 ± 2.3 vs 4.7 ± 1.6; immediate perception, 10.9 ± 2.8 vs 11.5 ± 1.8; and emotional response, 4.1 ± 7.6 vs 3.2 ± 7.5. MDP ratings had no relation to peak power output. Conclusion: Breathlessness dimensions are similar at the peak of a standardized IET and cannot differentiate between people with normal and abnormally high exertional breathlessness.</p>}}, author = {{Elmberg, Viktor and Ali, Gufran and Gustafsson, David and Jensen, Dennis and Ekström, Magnus}}, issn = {{1569-9048}}, keywords = {{Breathlessness; Dyspnea; Exercise testing; MDP; Multiple dyspnoea profile}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Respiratory Physiology and Neurobiology}}, title = {{Breathlessness dimensions should be evaluated in relation to the level of exertion : A clinical study}}, url = {{http://dx.doi.org/10.1016/j.resp.2025.104398}}, doi = {{10.1016/j.resp.2025.104398}}, volume = {{333}}, year = {{2025}}, }