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Bioinspired Structural Hierarchy within Macroscopic Volumes of Synthetic Composites

Rajasekharan, Anand K.; Lotsari, Antiope; Lutz-Bueno, Viviane; Liebi, Marianne LU and Andersson, Martin (2018) In Advanced healthcare materials 7(18).
Abstract

A key challenge in developing bioinspired composites is the fabrication of well-defined 3D hierarchical structures ranging from nano to the macroscale. Herein, the development of a synthetic polymer-apatite composite realized by integrating bottom-up self-assembly and additive manufacturing (AM) is described. The resulting composite exhibits a bioinspired hierarchical structure over its 3D macroscopic volume. The composite is assembled in a bottom-up manner, where periodic nanoscale assemblies of organic micellar fibrils and inorganic apatite nanocrystals are organized as bundles of mineralized microstructures. These microstructural bundles are preferentially oriented throughout the macroscopic volume of the material via extrusion based... (More)

A key challenge in developing bioinspired composites is the fabrication of well-defined 3D hierarchical structures ranging from nano to the macroscale. Herein, the development of a synthetic polymer-apatite composite realized by integrating bottom-up self-assembly and additive manufacturing (AM) is described. The resulting composite exhibits a bioinspired hierarchical structure over its 3D macroscopic volume. The composite is assembled in a bottom-up manner, where periodic nanoscale assemblies of organic micellar fibrils and inorganic apatite nanocrystals are organized as bundles of mineralized microstructures. These microstructural bundles are preferentially oriented throughout the macroscopic volume of the material via extrusion based AM. The obtained structural hierarchy is investigated in 3D using electron microscopy and small angle X-ray scattering tensor tomography and correlated to the structural hierarchy and anisotropy observed in biological tissues such as bone and the bone-cartilage interface. This work demonstrates the possibility to form polymer-apatite composites with a well-defined hierarchical structure throughout its macroscopic volume, which is crucial for the development of mechanically optimized materials for applications such as bone and osteochondral implants.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anisotropy, Bioinspired composites, Macroscopic volume, Small angle X-ray scattering, Structural hierarchy
in
Advanced healthcare materials
volume
7
issue
18
publisher
John Wiley and Sons Ltd
external identifiers
  • scopus:85051078055
ISSN
2192-2640
DOI
10.1002/adhm.201800466
language
English
LU publication?
yes
id
b8b0749a-adcc-42ef-a7b6-a3ebb01530d3
date added to LUP
2018-09-13 10:59:19
date last changed
2019-01-14 18:02:14
@article{b8b0749a-adcc-42ef-a7b6-a3ebb01530d3,
  abstract     = {<p>A key challenge in developing bioinspired composites is the fabrication of well-defined 3D hierarchical structures ranging from nano to the macroscale. Herein, the development of a synthetic polymer-apatite composite realized by integrating bottom-up self-assembly and additive manufacturing (AM) is described. The resulting composite exhibits a bioinspired hierarchical structure over its 3D macroscopic volume. The composite is assembled in a bottom-up manner, where periodic nanoscale assemblies of organic micellar fibrils and inorganic apatite nanocrystals are organized as bundles of mineralized microstructures. These microstructural bundles are preferentially oriented throughout the macroscopic volume of the material via extrusion based AM. The obtained structural hierarchy is investigated in 3D using electron microscopy and small angle X-ray scattering tensor tomography and correlated to the structural hierarchy and anisotropy observed in biological tissues such as bone and the bone-cartilage interface. This work demonstrates the possibility to form polymer-apatite composites with a well-defined hierarchical structure throughout its macroscopic volume, which is crucial for the development of mechanically optimized materials for applications such as bone and osteochondral implants.</p>},
  articleno    = {1800466},
  author       = {Rajasekharan, Anand K. and Lotsari, Antiope and Lutz-Bueno, Viviane and Liebi, Marianne and Andersson, Martin},
  issn         = {2192-2640},
  keyword      = {Anisotropy,Bioinspired composites,Macroscopic volume,Small angle X-ray scattering,Structural hierarchy},
  language     = {eng},
  month        = {07},
  number       = {18},
  publisher    = {John Wiley and Sons Ltd},
  series       = {Advanced healthcare materials},
  title        = {Bioinspired Structural Hierarchy within Macroscopic Volumes of Synthetic Composites},
  url          = {http://dx.doi.org/10.1002/adhm.201800466},
  volume       = {7},
  year         = {2018},
}