Atopic dermatitis, systemic inflammation and subsequent dementia risk
(2023) In JEADV Clinical Practice 2(4). p.839-848- Abstract
Background: Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives: This study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk. Methods: We used three Swedish register-based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician-assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783)... (More)
Background: Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives: This study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk. Methods: We used three Swedish register-based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician-assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow-up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings. Results: Cohort I: 1466 dementia events were accrued during follow-up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person-years. Cohort II: 3549 dementia events were accrued during follow-up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person-years. Cohort III: 120,303 dementia events were accrued during follow-up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person-years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)]. Conclusions: AD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence.
(Less)
- author
- Vingeliene, Snieguole ; Hiyoshi, Ayako ; Carlberg, M. ; Garcia-Argibay, Miguel ; Lentjes, M. ; Fall, Katja ; von Kobyletzki, Laura LU and Montgomery, Scott
- organization
- publishing date
- 2023-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atopic dermatitis, dementia, erythrocyte sedimentation rate
- in
- JEADV Clinical Practice
- volume
- 2
- issue
- 4
- pages
- 10 pages
- publisher
- Wiley
- external identifiers
-
- scopus:85181467049
- ISSN
- 2768-6566
- DOI
- 10.1002/jvc2.249
- language
- English
- LU publication?
- yes
- id
- b8d2d581-5319-400d-8ef5-b7df24581c74
- date added to LUP
- 2024-02-16 11:51:52
- date last changed
- 2025-04-04 14:48:39
@article{b8d2d581-5319-400d-8ef5-b7df24581c74,
abstract = {{<p>Background: Atopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia. Objectives: This study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk. Methods: We used three Swedish register-based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician-assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow-up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings. Results: Cohort I: 1466 dementia events were accrued during follow-up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person-years. Cohort II: 3549 dementia events were accrued during follow-up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person-years. Cohort III: 120,303 dementia events were accrued during follow-up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person-years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)]. Conclusions: AD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence.</p>}},
author = {{Vingeliene, Snieguole and Hiyoshi, Ayako and Carlberg, M. and Garcia-Argibay, Miguel and Lentjes, M. and Fall, Katja and von Kobyletzki, Laura and Montgomery, Scott}},
issn = {{2768-6566}},
keywords = {{atopic dermatitis; dementia; erythrocyte sedimentation rate}},
language = {{eng}},
number = {{4}},
pages = {{839--848}},
publisher = {{Wiley}},
series = {{JEADV Clinical Practice}},
title = {{Atopic dermatitis, systemic inflammation and subsequent dementia risk}},
url = {{http://dx.doi.org/10.1002/jvc2.249}},
doi = {{10.1002/jvc2.249}},
volume = {{2}},
year = {{2023}},
}