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Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Borgström, Björn LU ; Huang, Xiaoli LU ; Posta, Martin LU ; Hegardt, Cecilia LU ; Oredsson, Stina LU and Strand, Daniel LU (2013) In Chemical Communications 49(85). p.9944-9946
Abstract
Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Communications
volume
49
issue
85
pages
3 pages
publisher
Royal Society of Chemistry
external identifiers
  • wos:000325367500016
  • scopus:84885121121
  • pmid:24037337
ISSN
1364-548X
DOI
10.1039/c3cc45983g
language
English
LU publication?
yes
id
b8ff4cdf-33bc-4d7b-b50f-8c528ffef635 (old id 4172459)
date added to LUP
2016-04-01 11:09:17
date last changed
2023-08-31 19:49:16
@article{b8ff4cdf-33bc-4d7b-b50f-8c528ffef635,
  abstract     = {{Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.}},
  author       = {{Borgström, Björn and Huang, Xiaoli and Posta, Martin and Hegardt, Cecilia and Oredsson, Stina and Strand, Daniel}},
  issn         = {{1364-548X}},
  language     = {{eng}},
  number       = {{85}},
  pages        = {{9944--9946}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Chemical Communications}},
  title        = {{Synthetic modification of salinomycin: selective O-acylation and biological evaluation}},
  url          = {{http://dx.doi.org/10.1039/c3cc45983g}},
  doi          = {{10.1039/c3cc45983g}},
  volume       = {{49}},
  year         = {{2013}},
}