Synthetic modification of salinomycin: selective O-acylation and biological evaluation
(2013) In Chemical Communications 49(85). p.9944-9946- Abstract
- Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172459
- author
- Borgström, Björn LU ; Huang, Xiaoli LU ; Posta, Martin LU ; Hegardt, Cecilia LU ; Oredsson, Stina LU and Strand, Daniel LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chemical Communications
- volume
- 49
- issue
- 85
- pages
- 3 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000325367500016
- scopus:84885121121
- pmid:24037337
- ISSN
- 1364-548X
- DOI
- 10.1039/c3cc45983g
- language
- English
- LU publication?
- yes
- id
- b8ff4cdf-33bc-4d7b-b50f-8c528ffef635 (old id 4172459)
- date added to LUP
- 2016-04-01 11:09:17
- date last changed
- 2023-08-31 19:49:16
@article{b8ff4cdf-33bc-4d7b-b50f-8c528ffef635, abstract = {{Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.}}, author = {{Borgström, Björn and Huang, Xiaoli and Posta, Martin and Hegardt, Cecilia and Oredsson, Stina and Strand, Daniel}}, issn = {{1364-548X}}, language = {{eng}}, number = {{85}}, pages = {{9944--9946}}, publisher = {{Royal Society of Chemistry}}, series = {{Chemical Communications}}, title = {{Synthetic modification of salinomycin: selective O-acylation and biological evaluation}}, url = {{http://dx.doi.org/10.1039/c3cc45983g}}, doi = {{10.1039/c3cc45983g}}, volume = {{49}}, year = {{2013}}, }