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REDOX regulation of mitochondrial function in plants

Giraud, Estelle; Van Aken, Olivier LU ; Uggalla, Vindya and Whelan, James (2012) In Plant, Cell and Environment 35(2). p.80-271
Abstract

Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various internal or external cues. At the transcript level, large-scale changes in groups of genes suggest the presence of co-regulatory mechanisms for these components. Furthermore, the pathways that regulate these changes appear to be integrated into regulatory pathways that alter a variety of functions in cells. However, the changes in transcripts are... (More)

Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various internal or external cues. At the transcript level, large-scale changes in groups of genes suggest the presence of co-regulatory mechanisms for these components. Furthermore, the pathways that regulate these changes appear to be integrated into regulatory pathways that alter a variety of functions in cells. However, the changes in transcripts are not always observed at the protein or the metabolite level. This is likely to be due to post-transcriptional levels of regulation and also the fact that in-depth profiles, which have been obtained for transcripts from a variety of studies, are currently not available for proteins and metabolites. Thus, while transcripts for genes give us a picture of what the cells are 'thinking' in relation to mitochondrial components, some of these responses may be lost in translation.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gene Expression Regulation, Plant, Metabolomics, Mitochondria, Oxidation-Reduction, Oxidative Stress, Plants, Proteomics, Stress, Physiological, Transcriptome
in
Plant, Cell and Environment
volume
35
issue
2
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84855348301
ISSN
0140-7791
DOI
10.1111/j.1365-3040.2011.02293.x
language
English
LU publication?
no
id
b9569dbd-b25f-455a-b91f-bfb237742acb
date added to LUP
2017-05-09 10:07:19
date last changed
2017-05-30 13:55:43
@article{b9569dbd-b25f-455a-b91f-bfb237742acb,
  abstract     = {<p>Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various internal or external cues. At the transcript level, large-scale changes in groups of genes suggest the presence of co-regulatory mechanisms for these components. Furthermore, the pathways that regulate these changes appear to be integrated into regulatory pathways that alter a variety of functions in cells. However, the changes in transcripts are not always observed at the protein or the metabolite level. This is likely to be due to post-transcriptional levels of regulation and also the fact that in-depth profiles, which have been obtained for transcripts from a variety of studies, are currently not available for proteins and metabolites. Thus, while transcripts for genes give us a picture of what the cells are 'thinking' in relation to mitochondrial components, some of these responses may be lost in translation.</p>},
  author       = {Giraud, Estelle and Van Aken, Olivier and Uggalla, Vindya and Whelan, James},
  issn         = {0140-7791},
  keyword      = {Gene Expression Regulation, Plant,Metabolomics,Mitochondria,Oxidation-Reduction,Oxidative Stress,Plants,Proteomics,Stress, Physiological,Transcriptome},
  language     = {eng},
  number       = {2},
  pages        = {80--271},
  publisher    = {Wiley-Blackwell},
  series       = {Plant, Cell and Environment},
  title        = {REDOX regulation of mitochondrial function in plants},
  url          = {http://dx.doi.org/10.1111/j.1365-3040.2011.02293.x},
  volume       = {35},
  year         = {2012},
}