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Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases

Jian, Tianzi ; Xu, Fabao ; Li, Guihua ; Song, Boxuan ; Wang, Helei ; Yang, Xueying ; Zhai, Weibin ; Li, Xiangchen ; Li, Zhiwen and Feng, Qi , et al. (2024) In Scientific Reports 14(1).
Abstract

It is now understood that hematological diseases can have detrimental effects on the retina, reducing retinal capillaries, compromising visual function, and potentially causing irreversible visual impairment. Over the years, there has been limited research on macular microvascular abnormalities, such as changes in vessel density and the foveal avascular zone (FAZ) and variations in the severity of these effects across different types of blood disorders. This study aims to quantitatively assess the impact of various hematological disorders on the retina using optical coherence tomography angiography (OCTA). Compared with healthy eyes, patients with different blood diseases exhibited reductions in linear vessel density (LVD), perfusion... (More)

It is now understood that hematological diseases can have detrimental effects on the retina, reducing retinal capillaries, compromising visual function, and potentially causing irreversible visual impairment. Over the years, there has been limited research on macular microvascular abnormalities, such as changes in vessel density and the foveal avascular zone (FAZ) and variations in the severity of these effects across different types of blood disorders. This study aims to quantitatively assess the impact of various hematological disorders on the retina using optical coherence tomography angiography (OCTA). Compared with healthy eyes, patients with different blood diseases exhibited reductions in linear vessel density (LVD), perfusion vessel density (PVD), FAZ area, and FAZ perimeter. Notably, patients with erythrocyte diseases showed more significant abnormalities in LVD and PVD, while patients with lymphocytic diseases demonstrated more pronounced abnormalities in the FAZ area and perimeter. OCTA imaging could potentially reflect changes of the retinal microvascular of patients with hematological diseases and may serve as a valuable tool for distinguishing abnormalities affecting different blood cell lines. This approach offers a novel avenue for assessing, treating, and monitoring blood disorders.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Erythrocyte diseases, Lymphocyte diseases, Myelocyte diseases, Optical coherence tomography angiography, Pancytopenia diseases
in
Scientific Reports
volume
14
issue
1
article number
25433
publisher
Nature Publishing Group
external identifiers
  • scopus:85207629171
  • pmid:39455721
ISSN
2045-2322
DOI
10.1038/s41598-024-76753-8
language
English
LU publication?
yes
id
b96d53f4-6e3d-46d2-9c66-59fc312bfda1
date added to LUP
2024-12-03 12:25:13
date last changed
2024-12-17 13:51:09
@article{b96d53f4-6e3d-46d2-9c66-59fc312bfda1,
  abstract     = {{<p>It is now understood that hematological diseases can have detrimental effects on the retina, reducing retinal capillaries, compromising visual function, and potentially causing irreversible visual impairment. Over the years, there has been limited research on macular microvascular abnormalities, such as changes in vessel density and the foveal avascular zone (FAZ) and variations in the severity of these effects across different types of blood disorders. This study aims to quantitatively assess the impact of various hematological disorders on the retina using optical coherence tomography angiography (OCTA). Compared with healthy eyes, patients with different blood diseases exhibited reductions in linear vessel density (LVD), perfusion vessel density (PVD), FAZ area, and FAZ perimeter. Notably, patients with erythrocyte diseases showed more significant abnormalities in LVD and PVD, while patients with lymphocytic diseases demonstrated more pronounced abnormalities in the FAZ area and perimeter. OCTA imaging could potentially reflect changes of the retinal microvascular of patients with hematological diseases and may serve as a valuable tool for distinguishing abnormalities affecting different blood cell lines. This approach offers a novel avenue for assessing, treating, and monitoring blood disorders.</p>}},
  author       = {{Jian, Tianzi and Xu, Fabao and Li, Guihua and Song, Boxuan and Wang, Helei and Yang, Xueying and Zhai, Weibin and Li, Xiangchen and Li, Zhiwen and Feng, Qi and Xu, Shuqian and Semple, John W. and Zhang, Li and Peng, Jun}},
  issn         = {{2045-2322}},
  keywords     = {{Erythrocyte diseases; Lymphocyte diseases; Myelocyte diseases; Optical coherence tomography angiography; Pancytopenia diseases}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-76753-8}},
  doi          = {{10.1038/s41598-024-76753-8}},
  volume       = {{14}},
  year         = {{2024}},
}