Absorption and metabolism of orally fed arachidonic acid and linoleic acid in the rat.
(1988) In American Journal of Physiology: Gastrointestinal and Liver Physiology 255(5 Pt 1). p.612-618- Abstract
- [3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wall increased, however, with time. This was due to a higher retention of [3H]20:4 than [14C]18:2 in intestinal phospholipids. In contrast, more of the [14C]18:2 was in triacylglycerol of the small intestine and plasma. The highest 3H:14C ratios were found in phosphatidylethanolamine and phosphatidylinositol. The 3H:14C ratio of intestinal... (More)
- [3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wall increased, however, with time. This was due to a higher retention of [3H]20:4 than [14C]18:2 in intestinal phospholipids. In contrast, more of the [14C]18:2 was in triacylglycerol of the small intestine and plasma. The highest 3H:14C ratios were found in phosphatidylethanolamine and phosphatidylinositol. The 3H:14C ratio of intestinal phosphatidylcholine varied with the type of fat vehicle used, being highest in the Intralipid experiments. After feeding Intralipid (30-60 min), significantly more of the plasma [3H]20:4 than plasma [14C]18:2 was in diacylglycerol, the 3H:14C ratio of which was much higher than that of plasma free fatty acids. [3H]20:4 and [14C]18:2 of chyle triacylglycerol are thus metabolized differently. (Less)
- Abstract (Swedish)
- [3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wall increased, however, with time. This was due to a higher retention of [3H]20:4 than [14C]18:2 in intestinal phospholipids. In contrast, more of the [14C]18:2 was in triacylglycerol of the small intestine and plasma. The highest 3H:14C ratios were found in phosphatidylethanolamine and phosphatidylinositol. The 3H:14C ratio of intestinal... (More)
- [3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wall increased, however, with time. This was due to a higher retention of [3H]20:4 than [14C]18:2 in intestinal phospholipids. In contrast, more of the [14C]18:2 was in triacylglycerol of the small intestine and plasma. The highest 3H:14C ratios were found in phosphatidylethanolamine and phosphatidylinositol. The 3H:14C ratio of intestinal phosphatidylcholine varied with the type of fat vehicle used, being highest in the Intralipid experiments. After feeding Intralipid (30-60 min), significantly more of the plasma [3H]20:4 than plasma [14C]18:2 was in diacylglycerol, the 3H:14C ratio of which was much higher than that of plasma free fatty acids. [3H]20:4 and [14C]18:2 of chyle triacylglycerol are thus metabolized differently. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b9771c50-7caf-4889-9c2c-0bbf7e02668f
- author
- Melin, Tor LU and Nilsson, Åke LU
- organization
- publishing date
- 1988-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Physiology: Gastrointestinal and Liver Physiology
- volume
- 255
- issue
- 5 Pt 1
- pages
- 612 - 618
- publisher
- American Physiological Society
- ISSN
- 1522-1547
- DOI
- 10.1152/ajpgi.1988.255.5.G612
- language
- English
- LU publication?
- yes
- id
- b9771c50-7caf-4889-9c2c-0bbf7e02668f
- date added to LUP
- 2019-05-24 13:53:07
- date last changed
- 2020-09-16 15:29:09
@article{b9771c50-7caf-4889-9c2c-0bbf7e02668f, abstract = {{[3H]arachidonic [( 3H]20:4) and [14C]linoleic acid [14C]18:2) were fed to rats in Intralipid or cream. Later (30-240 min) the stomach, small intestine, plasma, and liver were analyzed for radioactivity in different lipid classes. [3H]20:4 and [14C]18:2 were emptied from the stomach and absorbed by the intestine at similar rates. The [3H]20:4:[14C]18:2 ratio of the lipids in the small intestinal wall increased, however, with time. This was due to a higher retention of [3H]20:4 than [14C]18:2 in intestinal phospholipids. In contrast, more of the [14C]18:2 was in triacylglycerol of the small intestine and plasma. The highest 3H:14C ratios were found in phosphatidylethanolamine and phosphatidylinositol. The 3H:14C ratio of intestinal phosphatidylcholine varied with the type of fat vehicle used, being highest in the Intralipid experiments. After feeding Intralipid (30-60 min), significantly more of the plasma [3H]20:4 than plasma [14C]18:2 was in diacylglycerol, the 3H:14C ratio of which was much higher than that of plasma free fatty acids. [3H]20:4 and [14C]18:2 of chyle triacylglycerol are thus metabolized differently.}}, author = {{Melin, Tor and Nilsson, Åke}}, issn = {{1522-1547}}, language = {{eng}}, month = {{05}}, number = {{5 Pt 1}}, pages = {{612--618}}, publisher = {{American Physiological Society}}, series = {{American Journal of Physiology: Gastrointestinal and Liver Physiology}}, title = {{Absorption and metabolism of orally fed arachidonic acid and linoleic acid in the rat.}}, url = {{http://dx.doi.org/10.1152/ajpgi.1988.255.5.G612}}, doi = {{10.1152/ajpgi.1988.255.5.G612}}, volume = {{255}}, year = {{1988}}, }