High concentration of thyrotropin-releasing hormone in pancreatic islets
Martino, E ; Lernmark, Åke LU
; Seo, H
; Steiner, D F
and Refetoff, S
(1978)
In Proceedings of the National Academy of Sciences of the United States of America
75(9).
p.7-4265
- Abstract
The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of islet TRH is unknown. However, because TRH is antagonistic to somatostatin in other systems, and somatostatin also is concentrated in islets in high concentrations, it is possible that islet TRH may serve a similar antagonistic function in the regulation of islet cell secretory activity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b9955471-feaf-45e7-b885-004a7093349c
- author
- Martino, E
; Lernmark, Åke
LU
; Seo, H
; Steiner, D F
and Refetoff, S
- publishing date
- 1978
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Diabetes Mellitus, Experimental/metabolism, Islets of Langerhans/metabolism, Male, Radioimmunoassay, Rats, Species Specificity, Thyrotropin-Releasing Hormone/metabolism
- in
- Proceedings of the National Academy of Sciences of the United States of America
- volume
- 75
- issue
- 9
- pages
- 7 - 4265
- publisher
- National Academy of Sciences
- external identifiers
-
- scopus:0018127943
- pmid:100783
- ISSN
- 0027-8424
- DOI
- 10.1073/pnas.75.9.4265
- language
- English
- LU publication?
- no
- id
- b9955471-feaf-45e7-b885-004a7093349c
- date added to LUP
- 2021-09-07 15:56:40
- date last changed
- 2024-03-13 08:17:14
@article{b9955471-feaf-45e7-b885-004a7093349c,
abstract = {{<p>The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of islet TRH is unknown. However, because TRH is antagonistic to somatostatin in other systems, and somatostatin also is concentrated in islets in high concentrations, it is possible that islet TRH may serve a similar antagonistic function in the regulation of islet cell secretory activity.</p>}},
author = {{Martino, E and Lernmark, Åke and Seo, H and Steiner, D F and Refetoff, S}},
issn = {{0027-8424}},
keywords = {{Animals; Diabetes Mellitus, Experimental/metabolism; Islets of Langerhans/metabolism; Male; Radioimmunoassay; Rats; Species Specificity; Thyrotropin-Releasing Hormone/metabolism}},
language = {{eng}},
number = {{9}},
pages = {{7--4265}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences of the United States of America}},
title = {{High concentration of thyrotropin-releasing hormone in pancreatic islets}},
url = {{http://dx.doi.org/10.1073/pnas.75.9.4265}},
doi = {{10.1073/pnas.75.9.4265}},
volume = {{75}},
year = {{1978}},
}