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Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats

Meissner, Wlodzimierz; Reum, Torsten; Paul, G LU ; Harnack, Daniel; Sohr, Reinhard; Morgenstern, R and Kupsch, A (2001) In Neuroscience Letters 303(3). p.8-165
Abstract

Deep brain stimulation of the subthalamic nucleus is an established therapeutic strategy for patients with Parkinson's disease. Although the exact mechanisms of action remain unknown, it is noteworthy that dopaminergic medication can be markedly reduced after neurostimulation of the subthalamic nucleus. Previously, we have shown that deep brain stimulation of the subthalamic nucleus is followed by an increase of striatal extracellular dopamine metabolites in naive rats. In the present study we examined the effects of deep brain stimulation on striatal monoamine metabolism in the intrastriatal 6-hydroxydopamine rat model of Parkinson's disease. Deep brain stimulation of the subthalamic nucleus was followed by a delayed increase of... (More)

Deep brain stimulation of the subthalamic nucleus is an established therapeutic strategy for patients with Parkinson's disease. Although the exact mechanisms of action remain unknown, it is noteworthy that dopaminergic medication can be markedly reduced after neurostimulation of the subthalamic nucleus. Previously, we have shown that deep brain stimulation of the subthalamic nucleus is followed by an increase of striatal extracellular dopamine metabolites in naive rats. In the present study we examined the effects of deep brain stimulation on striatal monoamine metabolism in the intrastriatal 6-hydroxydopamine rat model of Parkinson's disease. Deep brain stimulation of the subthalamic nucleus was followed by a delayed increase of extracellular 3,4-dihydroxyphenylacetic and homovanillic whereas dopamine levels were unchanged in stimulated rats and controls. Our results indicate that deep brain stimulation of the subthalamic nucleus affects significantly striatal dopaminergic metabolism in 6-hydroxydopamine lesioned rats.

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published
keywords
3,4-Dihydroxyphenylacetic Acid, Animals, Dopamine, Electric Stimulation Therapy, Extracellular Space, Homovanillic Acid, Male, Microdialysis, Neostriatum, Oxidopamine, Parkinsonian Disorders, Rats, Rats, Wistar, Subthalamic Nucleus, Sympatholytics, Journal Article, Research Support, Non-U.S. Gov't
in
Neuroscience Letters
volume
303
issue
3
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0035843916
ISSN
0304-3940
language
English
LU publication?
no
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b9d5b3b9-c9d6-4664-9fd8-fa41b6045f36
date added to LUP
2017-05-18 12:46:14
date last changed
2018-01-07 12:04:16
@article{b9d5b3b9-c9d6-4664-9fd8-fa41b6045f36,
  abstract     = {<p>Deep brain stimulation of the subthalamic nucleus is an established therapeutic strategy for patients with Parkinson's disease. Although the exact mechanisms of action remain unknown, it is noteworthy that dopaminergic medication can be markedly reduced after neurostimulation of the subthalamic nucleus. Previously, we have shown that deep brain stimulation of the subthalamic nucleus is followed by an increase of striatal extracellular dopamine metabolites in naive rats. In the present study we examined the effects of deep brain stimulation on striatal monoamine metabolism in the intrastriatal 6-hydroxydopamine rat model of Parkinson's disease. Deep brain stimulation of the subthalamic nucleus was followed by a delayed increase of extracellular 3,4-dihydroxyphenylacetic and homovanillic whereas dopamine levels were unchanged in stimulated rats and controls. Our results indicate that deep brain stimulation of the subthalamic nucleus affects significantly striatal dopaminergic metabolism in 6-hydroxydopamine lesioned rats.</p>},
  author       = {Meissner, Wlodzimierz and Reum, Torsten and Paul, G and Harnack, Daniel and Sohr, Reinhard and Morgenstern, R and Kupsch, A},
  issn         = {0304-3940},
  keyword      = {3,4-Dihydroxyphenylacetic Acid,Animals,Dopamine,Electric Stimulation Therapy,Extracellular Space,Homovanillic Acid,Male,Microdialysis,Neostriatum,Oxidopamine,Parkinsonian Disorders,Rats,Rats, Wistar,Subthalamic Nucleus,Sympatholytics,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {05},
  number       = {3},
  pages        = {8--165},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats},
  volume       = {303},
  year         = {2001},
}