Thromboinflammation in Brain Ischemia : Recent Updates and Future Perspectives
(2022) In Stroke 53(5). p.1487-1499- Abstract
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all... (More)
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.
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- author
- De Meyer, Simon F. ; Langhauser, Friederike ; Haupeltshofer, Steffen LU ; Kleinschnitz, Christoph and Casas, Ana I.
- publishing date
- 2022-05-01
- type
- Contribution to journal
- publication status
- published
- keywords
- inflammation, ischemic stroke, microglia, thromboinflammation, thrombosis
- in
- Stroke
- volume
- 53
- issue
- 5
- pages
- 1487 - 1499
- publisher
- American Heart Association
- external identifiers
-
- pmid:35360931
- scopus:85129260248
- ISSN
- 0039-2499
- DOI
- 10.1161/STROKEAHA.122.038733
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.
- id
- b9e3222b-6698-4725-835f-ead0fec7aa23
- date added to LUP
- 2026-02-04 15:44:51
- date last changed
- 2026-02-04 15:45:52
@article{b9e3222b-6698-4725-835f-ead0fec7aa23,
abstract = {{<p>Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.</p>}},
author = {{De Meyer, Simon F. and Langhauser, Friederike and Haupeltshofer, Steffen and Kleinschnitz, Christoph and Casas, Ana I.}},
issn = {{0039-2499}},
keywords = {{inflammation; ischemic stroke; microglia; thromboinflammation; thrombosis}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{1487--1499}},
publisher = {{American Heart Association}},
series = {{Stroke}},
title = {{Thromboinflammation in Brain Ischemia : Recent Updates and Future Perspectives}},
url = {{http://dx.doi.org/10.1161/STROKEAHA.122.038733}},
doi = {{10.1161/STROKEAHA.122.038733}},
volume = {{53}},
year = {{2022}},
}