Alzheimer's disease and the cerebellum: a morphologic study on neuronal and glial changes
Sjöbeck, Martin LU and Englund, Elisabet LU
(2001)
In Dementia and Geriatric Cognitive Disorders
12(3).
p.211-218
- Abstract
- Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The... (More)
- Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The structural cerebellar changes in the AD cases were thus neuronal loss, atrophy and gliosis, judged to represent the disease process, and with a main involvement in the vermis. This may be reflected in some of the symptoms and signs seen in AD, signs that are generally overlooked or judged to be of noncerebellar origin. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121936
- author
- Sjöbeck, Martin
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebellum, Alzheimer's disease, Purkinje cells, Neuronal counting, Inferior olivary nucleus, Gliosis, Atrophy
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 12
- issue
- 3
- pages
- 211 - 218
- publisher
- Karger
- external identifiers
-
- pmid:11244215
- scopus:0035106551
- ISSN
- 1420-8008
- DOI
- 10.1159/000051260
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)
- id
- b9e67269-b1c7-46de-92b5-df1ab9aafa6d (old id 1121936)
- date added to LUP
- 2016-04-01 11:50:09
- date last changed
- 2022-01-26 18:57:58
@article{b9e67269-b1c7-46de-92b5-df1ab9aafa6d,
abstract = {{Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The structural cerebellar changes in the AD cases were thus neuronal loss, atrophy and gliosis, judged to represent the disease process, and with a main involvement in the vermis. This may be reflected in some of the symptoms and signs seen in AD, signs that are generally overlooked or judged to be of noncerebellar origin.}},
author = {{Sjöbeck, Martin and Englund, Elisabet}},
issn = {{1420-8008}},
keywords = {{Cerebellum; Alzheimer's disease; Purkinje cells; Neuronal counting; Inferior olivary nucleus; Gliosis; Atrophy}},
language = {{eng}},
number = {{3}},
pages = {{211--218}},
publisher = {{Karger}},
series = {{Dementia and Geriatric Cognitive Disorders}},
title = {{Alzheimer's disease and the cerebellum: a morphologic study on neuronal and glial changes}},
url = {{http://dx.doi.org/10.1159/000051260}},
doi = {{10.1159/000051260}},
volume = {{12}},
year = {{2001}},
}