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Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects

Högman, M. ; Thornadtsson, A. ; Liv, P. ; Hua-Huy, T. ; Dinh-Xuan, A. T. ; Tufvesson, E. LU ; Dressel, H. ; Janson, C. ; Koskela, K. and Oksa, P. , et al. (2017) In Journal of Breath Research 11(4).
Abstract

The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (JawNO), airway diffusing capacity (DawNO) and airway wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n = 433) ranged in age from 7 to 78 years. Age-stratified reference values... (More)

The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (JawNO), airway diffusing capacity (DawNO) and airway wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n = 433) ranged in age from 7 to 78 years. Age-stratified reference values of the NO parameters were significantly different. Gender differences were only observed in the 20-49 age group. The results from the multiple regression models in subjects older than 20 years revealed that age, height and gender interaction together explained 6% of variation in FENO at 50 ml s-1 (FENO50), 4% in JawNO, 16% in CawNO, 8% in DawNO and 12% in CANO. In conclusion, in this study we have generated reference values for NO parameters from an extended NO analysis of healthy subjects. This is important in order to be able to use these parameters in clinical practice.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breath test, health, mathematical model, nitric oxide, pulmonary gas exchange
in
Journal of Breath Research
volume
11
issue
4
article number
047103
publisher
IOP Publishing
external identifiers
  • scopus:85038900966
  • pmid:28612760
ISSN
1752-7155
DOI
10.1088/1752-7163/aa7957
language
English
LU publication?
yes
id
b9e93e52-ca6f-4c2d-862b-9f9056de8444
date added to LUP
2018-01-22 18:02:17
date last changed
2024-05-13 04:13:59
@article{b9e93e52-ca6f-4c2d-862b-9f9056de8444,
  abstract     = {{<p>The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (F<sub>E</sub>NO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (C<sub>A</sub>NO), airway flux (J<sub>aw</sub>NO), airway diffusing capacity (D<sub>aw</sub>NO) and airway wall content (C<sub>aw</sub>NO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n = 433) ranged in age from 7 to 78 years. Age-stratified reference values of the NO parameters were significantly different. Gender differences were only observed in the 20-49 age group. The results from the multiple regression models in subjects older than 20 years revealed that age, height and gender interaction together explained 6% of variation in F<sub>E</sub>NO at 50 ml s<sup>-1</sup> (F<sub>E</sub>NO<sub>50</sub>), 4% in J<sub>aw</sub>NO, 16% in C<sub>aw</sub>NO, 8% in D<sub>aw</sub>NO and 12% in C<sub>A</sub>NO. In conclusion, in this study we have generated reference values for NO parameters from an extended NO analysis of healthy subjects. This is important in order to be able to use these parameters in clinical practice.</p>}},
  author       = {{Högman, M. and Thornadtsson, A. and Liv, P. and Hua-Huy, T. and Dinh-Xuan, A. T. and Tufvesson, E. and Dressel, H. and Janson, C. and Koskela, K. and Oksa, P. and Sauni, R. and Uitti, J. and Moilanen, E. and Lehtimäki, L.}},
  issn         = {{1752-7155}},
  keywords     = {{breath test; health; mathematical model; nitric oxide; pulmonary gas exchange}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{IOP Publishing}},
  series       = {{Journal of Breath Research}},
  title        = {{Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects}},
  url          = {{http://dx.doi.org/10.1088/1752-7163/aa7957}},
  doi          = {{10.1088/1752-7163/aa7957}},
  volume       = {{11}},
  year         = {{2017}},
}