Postoperativ morbiditet blandt alkoholmisbrugere.
(1994) In Ugeskrift for Laeger 156(3). p.287-290- Abstract
Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, diagnosis anesthesia, and surgery to 15 control persons who were consuming no more than two drinks daily. None of the patients showed signs of liver disease. The alcohol group developed more postoperative complications than controls (67 vs 20%, p < 0.05) and hospital stay was prolonged (20 vs 12 days, p < 0.05). Preoperatively, alcohol... (More)
Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, diagnosis anesthesia, and surgery to 15 control persons who were consuming no more than two drinks daily. None of the patients showed signs of liver disease. The alcohol group developed more postoperative complications than controls (67 vs 20%, p < 0.05) and hospital stay was prolonged (20 vs 12 days, p < 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (54 vs 68%, p < 0.01). Delayed-type hypersensitivity responses were reduced in the alcohol group before (53 mm2 vs 78, p < 0.05) and after (18 mm2 vs 55, p < 0.01) surgery. Alcohol misusers had significantly longer bleeding times. Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcohol misusers (p < 0.05). Postoperative morbidity was increased in alcohol misusers without signs of liver damage. The mechanisms may include subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor for postoperative morbidity than previously thought.
(Less)
- author
- Tønnesen, H. LU ; Petersen, K. R. ; Højgaard, L. ; Stokholm, K. H. ; Nielsen, H. J. ; Knigge, U. P. and Kehlet, H.
- alternative title
- Postoperative morbidity among alcohol abusers
- publishing date
- 1994-01-17
- type
- Contribution to journal
- publication status
- published
- in
- Ugeskrift for Laeger
- volume
- 156
- issue
- 3
- pages
- 4 pages
- publisher
- Den Almindelige Danske Lægeforening
- external identifiers
-
- pmid:8296417
- scopus:0028775512
- ISSN
- 0041-5782
- language
- Danish
- LU publication?
- no
- id
- ba437097-26b8-4f8a-800f-bae70145ed0d
- date added to LUP
- 2022-10-31 16:46:30
- date last changed
- 2024-01-02 20:09:48
@article{ba437097-26b8-4f8a-800f-bae70145ed0d,
abstract = {{<p>Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, diagnosis anesthesia, and surgery to 15 control persons who were consuming no more than two drinks daily. None of the patients showed signs of liver disease. The alcohol group developed more postoperative complications than controls (67 vs 20%, p < 0.05) and hospital stay was prolonged (20 vs 12 days, p < 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (54 vs 68%, p < 0.01). Delayed-type hypersensitivity responses were reduced in the alcohol group before (53 mm2 vs 78, p < 0.05) and after (18 mm2 vs 55, p < 0.01) surgery. Alcohol misusers had significantly longer bleeding times. Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcohol misusers (p < 0.05). Postoperative morbidity was increased in alcohol misusers without signs of liver damage. The mechanisms may include subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor for postoperative morbidity than previously thought.</p>}},
author = {{Tønnesen, H. and Petersen, K. R. and Højgaard, L. and Stokholm, K. H. and Nielsen, H. J. and Knigge, U. P. and Kehlet, H.}},
issn = {{0041-5782}},
language = {{dan}},
month = {{01}},
number = {{3}},
pages = {{287--290}},
publisher = {{Den Almindelige Danske Lægeforening}},
series = {{Ugeskrift for Laeger}},
title = {{Postoperativ morbiditet blandt alkoholmisbrugere.}},
volume = {{156}},
year = {{1994}},
}