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Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

Jabbari, Reza; Jabbari, Javad; Glinge, Charlotte; Risgaard, Bjarke; Sattler, Stefan; Winkel, Bo Gregers; Terkelsen, Christian Juhl; Tilsted, Hans Henrik; Jensen, Lisette Okkels and Hougaard, Mikkel, et al. (2017) In BMC Medical Genetics 18(1).
Abstract

Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to... (More)

Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model. Conclusion: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

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keywords
Atrial fibrillation, Genetics, Myocardial infarction, Single nucleotide polymorphisms, ST-elevation myocardial infarction, Sudden cardiac death, Ventricular fibrillation
in
BMC Medical Genetics
volume
18
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85034659710
  • wos:000415874100004
ISSN
1471-2350
DOI
10.1186/s12881-017-0497-1
language
English
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yes
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bab4e6bd-9055-4d58-83fc-927ad8fea57d
date added to LUP
2017-12-14 12:43:23
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2018-01-16 13:27:50
@article{bab4e6bd-9055-4d58-83fc-927ad8fea57d,
  abstract     = {<p>Background: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI). Methods: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry. Results: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p &lt; 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model. Conclusion: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.</p>},
  articleno    = {138},
  author       = {Jabbari, Reza and Jabbari, Javad and Glinge, Charlotte and Risgaard, Bjarke and Sattler, Stefan and Winkel, Bo Gregers and Terkelsen, Christian Juhl and Tilsted, Hans Henrik and Jensen, Lisette Okkels and Hougaard, Mikkel and Haunsø, Stig and Engstrøm, Thomas and Albert, Christine M. and Tfelt-Hansen, Jacob},
  issn         = {1471-2350},
  keyword      = {Atrial fibrillation,Genetics,Myocardial infarction,Single nucleotide polymorphisms,ST-elevation myocardial infarction,Sudden cardiac death,Ventricular fibrillation},
  language     = {eng},
  month        = {11},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Medical Genetics},
  title        = {Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction},
  url          = {http://dx.doi.org/10.1186/s12881-017-0497-1},
  volume       = {18},
  year         = {2017},
}