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Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle

Heerschap, Arend; Houtman, C; in 't Zandt, H J LU ; van den Bergh, A J and Wieringa, B (1999) In Proceedings of the Nutrition Society 58(4). p.70-861
Abstract

31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusing on human applications, but with some illustrative examples from studies on transgenic mice. Topics which are described in the present paper are the information content of the 31P magnetic resonance spectrum of skeletal muscle, some practical issues in the performance of this MRS methodology, related muscle biochemistry and the validity of... (More)

31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusing on human applications, but with some illustrative examples from studies on transgenic mice. Topics which are described in the present paper are the information content of the 31P magnetic resonance spectrum of skeletal muscle, some practical issues in the performance of this MRS methodology, related muscle biochemistry and the validity of interpreting results in terms of biochemical processes, the possibility of investigating reaction kinetics in vivo and some indications for fibre-type heterogeneity as seen in spectra obtained during exercise.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Energy Metabolism, Exercise, Humans, Hydrogen-Ion Concentration, Kinetics, Magnetic Resonance Spectroscopy, Muscle, Skeletal, Phosphorus Isotopes, Journal Article, Review
in
Proceedings of the Nutrition Society
volume
58
issue
4
pages
10 pages
publisher
Cambridge University Press
external identifiers
  • scopus:0033237420
ISSN
0029-6651
DOI
10.1017/S0029665199001160
language
English
LU publication?
no
id
bac4d969-3b49-4bcf-9ef4-07b515b06b7c
date added to LUP
2017-03-06 16:49:58
date last changed
2017-04-13 13:33:11
@article{bac4d969-3b49-4bcf-9ef4-07b515b06b7c,
  abstract     = {<p>31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusing on human applications, but with some illustrative examples from studies on transgenic mice. Topics which are described in the present paper are the information content of the 31P magnetic resonance spectrum of skeletal muscle, some practical issues in the performance of this MRS methodology, related muscle biochemistry and the validity of interpreting results in terms of biochemical processes, the possibility of investigating reaction kinetics in vivo and some indications for fibre-type heterogeneity as seen in spectra obtained during exercise.</p>},
  author       = {Heerschap, Arend and Houtman, C and in 't Zandt, H J and van den Bergh, A J and Wieringa, B},
  issn         = {0029-6651},
  keyword      = {Animals,Energy Metabolism,Exercise,Humans,Hydrogen-Ion Concentration,Kinetics,Magnetic Resonance Spectroscopy,Muscle, Skeletal,Phosphorus Isotopes,Journal Article,Review},
  language     = {eng},
  number       = {4},
  pages        = {70--861},
  publisher    = {Cambridge University Press},
  series       = {Proceedings of the Nutrition Society},
  title        = {Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle},
  url          = {http://dx.doi.org/10.1017/S0029665199001160},
  volume       = {58},
  year         = {1999},
}