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Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop

Greenbaum, C. J. ; Palmer, J. P. ; Nagataki, S. ; Yamaguchi, Y. ; Molenaar, J. L. ; Van Beers, W. A.M. ; Maclaren, N. K. ; Lernmark, A. LU ; Villena, A. A. and Barbosa, J. , et al. (1992) In Diabetes 41(12). p.1570-1574
Abstract

The goal of the Fourth International Workshop for Standardization of ICA Measurements was to determine the specificity of ICA assays and their ability to distinguish between control sera (n = 57) and sera from IDDM-related individuals-representing relatives of IDDM patients (n = 21), healthy individuals who later developed IDDM (n = 8), or newly diagnosed IDDM patients (n = 23). Results from 28 laboratories were analyzed. The mean specificity (percentage of control sera reported as negative) among 27 laboratories was 91%, including 6 laboratories with 100% specificity. Nevertheless, 78% of laboratories found at least one control sample >0 JDF U. Among samples from first-degree relatives, the mean concordance was 86%, including three... (More)

The goal of the Fourth International Workshop for Standardization of ICA Measurements was to determine the specificity of ICA assays and their ability to distinguish between control sera (n = 57) and sera from IDDM-related individuals-representing relatives of IDDM patients (n = 21), healthy individuals who later developed IDDM (n = 8), or newly diagnosed IDDM patients (n = 23). Results from 28 laboratories were analyzed. The mean specificity (percentage of control sera reported as negative) among 27 laboratories was 91%, including 6 laboratories with 100% specificity. Nevertheless, 78% of laboratories found at least one control sample >0 JDF U. Among samples from first-degree relatives, the mean concordance was 86%, including three sera found negative (0 JDF U) by all laboratories. Among individuals who later developed diabetes, the mean concordance was 93%, with two sera found positive by 100% of laboratories. In sera from newly diagnosed IDDM patients, the mean concordance was 82%. Three sera were found positive and one serum negative by all laboratories. The JDF U of the sera considered to be positive were significantly greater than each laboratory's average for the controls. In conclusion, the results from laboratories participating in the Fourth International ICA Workshop demonstrated excellent specificity, good concordance, and an ability to separate control sera from defined, IDDM- related subjects.

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publishing date
type
Contribution to journal
publication status
published
in
Diabetes
volume
41
issue
12
pages
1570 - 1574
publisher
American Diabetes Association Inc.
external identifiers
  • pmid:1446798
  • scopus:0026539978
ISSN
0012-1797
DOI
10.2337/diab.41.12.1570
language
English
LU publication?
no
id
bb064096-9bdd-438a-bd28-67776bad76dc
date added to LUP
2019-09-11 09:33:45
date last changed
2020-01-13 02:21:04
@article{bb064096-9bdd-438a-bd28-67776bad76dc,
  abstract     = {<p>The goal of the Fourth International Workshop for Standardization of ICA Measurements was to determine the specificity of ICA assays and their ability to distinguish between control sera (n = 57) and sera from IDDM-related individuals-representing relatives of IDDM patients (n = 21), healthy individuals who later developed IDDM (n = 8), or newly diagnosed IDDM patients (n = 23). Results from 28 laboratories were analyzed. The mean specificity (percentage of control sera reported as negative) among 27 laboratories was 91%, including 6 laboratories with 100% specificity. Nevertheless, 78% of laboratories found at least one control sample &gt;0 JDF U. Among samples from first-degree relatives, the mean concordance was 86%, including three sera found negative (0 JDF U) by all laboratories. Among individuals who later developed diabetes, the mean concordance was 93%, with two sera found positive by 100% of laboratories. In sera from newly diagnosed IDDM patients, the mean concordance was 82%. Three sera were found positive and one serum negative by all laboratories. The JDF U of the sera considered to be positive were significantly greater than each laboratory's average for the controls. In conclusion, the results from laboratories participating in the Fourth International ICA Workshop demonstrated excellent specificity, good concordance, and an ability to separate control sera from defined, IDDM- related subjects.</p>},
  author       = {Greenbaum, C. J. and Palmer, J. P. and Nagataki, S. and Yamaguchi, Y. and Molenaar, J. L. and Van Beers, W. A.M. and Maclaren, N. K. and Lernmark, A. and Villena, A. A. and Barbosa, J. and DeBeaufort, C. and Becker, D. and Becker, F. and Betterle, C. and Bosi, E. and Bottazzo, G. F. and Bright, G. and Colman, P. and Dawkins, R. L.},
  issn         = {0012-1797},
  language     = {eng},
  month        = {01},
  number       = {12},
  pages        = {1570--1574},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop},
  url          = {http://dx.doi.org/10.2337/diab.41.12.1570},
  doi          = {10.2337/diab.41.12.1570},
  volume       = {41},
  year         = {1992},
}