Oligosaccharides from faeces of a blood-group B, breast-fed infant
(1988) In Carbohydrate Research 178(1). p.145-154- Abstract
- Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the... (More)
- Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104166
- author
- Sabharwal, Hemant ; Nilsson, Bo ; Chester, Alan LU ; Lindh, Frank ; Grönberg, Gunnar ; Sjöblad, Sture LU and Lundblad, Arne
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Carbohydrate Research
- volume
- 178
- issue
- 1
- pages
- 145 - 154
- publisher
- Elsevier
- external identifiers
-
- pmid:3191506
- scopus:0024288344
- ISSN
- 1873-426X
- DOI
- 10.1016/0008-6215(88)80107-1
- language
- English
- LU publication?
- yes
- id
- bb2a9271-4555-435a-ad33-577bac39212f (old id 1104166)
- date added to LUP
- 2016-04-01 11:33:42
- date last changed
- 2021-01-03 04:35:25
@article{bb2a9271-4555-435a-ad33-577bac39212f,
abstract = {{Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active.}},
author = {{Sabharwal, Hemant and Nilsson, Bo and Chester, Alan and Lindh, Frank and Grönberg, Gunnar and Sjöblad, Sture and Lundblad, Arne}},
issn = {{1873-426X}},
language = {{eng}},
number = {{1}},
pages = {{145--154}},
publisher = {{Elsevier}},
series = {{Carbohydrate Research}},
title = {{Oligosaccharides from faeces of a blood-group B, breast-fed infant}},
url = {{http://dx.doi.org/10.1016/0008-6215(88)80107-1}},
doi = {{10.1016/0008-6215(88)80107-1}},
volume = {{178}},
year = {{1988}},
}