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Modulation of carbon monoxide production and enhanced spatial learning by tin protoporphyrin

Bing, O ; Grundemar, L LU ; Ny, L ; Möller, C and Heilig, M (1995) In NeuroReport 6(10). p.1369-1372
Abstract

Endogenous carbon monoxide (CO), produced by haem oxygenase (HO), may play a role in hippocampal long-term potentiation (LTP). Its role in learning and memory in intact animals is less well known. Tin protoporphyrin (Sn-PP; 25 mg kg-1, i.p.) effectively but transiently inhibited HO activity in brain homogenates, and improved acquisition in the Morris water maze. Locomotor activity was unaffected, indicating a behavioural specificity of the learning effect. The analogue zinc protoporphyrin (25 mg kg-1, i.p.), which does not pass the blood-brain barrier, did not affect learning. If the observed memory effect is related to inhibition of HO, the role of CO in spatial learning may be different from that suggested by LTP studies.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Blood-Brain Barrier, Brain/drug effects, Carbon Monoxide/metabolism, Enzyme Inhibitors/pharmacology, Heme Oxygenase (Decyclizing)/antagonists & inhibitors, Long-Term Potentiation/drug effects, Male, Maze Learning/drug effects, Metalloporphyrins/pharmacology, Motor Activity/drug effects, Protoporphyrins/pharmacology, Rats, Rats, Wistar
in
NeuroReport
volume
6
issue
10
pages
1369 - 1372
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0029122409
  • pmid:7488726
ISSN
0959-4965
DOI
10.1097/00001756-199507100-00002
language
English
LU publication?
no
id
bb2f4366-17c0-4a51-b2d4-934a2f96f5e8
date added to LUP
2019-09-03 14:00:52
date last changed
2024-01-01 18:39:27
@article{bb2f4366-17c0-4a51-b2d4-934a2f96f5e8,
  abstract     = {{<p>Endogenous carbon monoxide (CO), produced by haem oxygenase (HO), may play a role in hippocampal long-term potentiation (LTP). Its role in learning and memory in intact animals is less well known. Tin protoporphyrin (Sn-PP; 25 mg kg-1, i.p.) effectively but transiently inhibited HO activity in brain homogenates, and improved acquisition in the Morris water maze. Locomotor activity was unaffected, indicating a behavioural specificity of the learning effect. The analogue zinc protoporphyrin (25 mg kg-1, i.p.), which does not pass the blood-brain barrier, did not affect learning. If the observed memory effect is related to inhibition of HO, the role of CO in spatial learning may be different from that suggested by LTP studies.</p>}},
  author       = {{Bing, O and Grundemar, L and Ny, L and Möller, C and Heilig, M}},
  issn         = {{0959-4965}},
  keywords     = {{Animals; Blood-Brain Barrier; Brain/drug effects; Carbon Monoxide/metabolism; Enzyme Inhibitors/pharmacology; Heme Oxygenase (Decyclizing)/antagonists & inhibitors; Long-Term Potentiation/drug effects; Male; Maze Learning/drug effects; Metalloporphyrins/pharmacology; Motor Activity/drug effects; Protoporphyrins/pharmacology; Rats; Rats, Wistar}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1369--1372}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Modulation of carbon monoxide production and enhanced spatial learning by tin protoporphyrin}},
  url          = {{http://dx.doi.org/10.1097/00001756-199507100-00002}},
  doi          = {{10.1097/00001756-199507100-00002}},
  volume       = {{6}},
  year         = {{1995}},
}