Nano-structuring for molecular motor control
Lard, Mercy LU ; Ten Siethoff, L. ; Kumar, S. ; Persson, M. ; te Kronnie, G. ; Månsson, A. and Linke, H. LU
(2015)
NATO Advanced Study Institute on Nano-Structures for Optics and Photonics: Optical Strategies for Enhancing Sensing, Imaging, Communication, and Energy Conversion
p.459-459
- Abstract
- The interaction of self-propelled biological molecular-motors and cytoskeletal filaments holds relevance for a variety of applications such as biosensing, drug screening, diagnostics and biocomputation. The use of these systems for lab-on-a-chip biotechnology applications shows potential for replacement of microfluidic flow by active, molecular-motor driven transport of filaments. The ability to control, confine and detect motile objects in such a system is possible by development of nanostructured surfaces for on-chip applications and fundamental studies of molecular-motors. Here we describe the localized detection (Lard et al., Sci Rep 3:1092, 2013) and fast transport of actin filaments by myosin molecular-motors (Lard et al., Biosens... (More)
- The interaction of self-propelled biological molecular-motors and cytoskeletal filaments holds relevance for a variety of applications such as biosensing, drug screening, diagnostics and biocomputation. The use of these systems for lab-on-a-chip biotechnology applications shows potential for replacement of microfluidic flow by active, molecular-motor driven transport of filaments. The ability to control, confine and detect motile objects in such a system is possible by development of nanostructured surfaces for on-chip applications and fundamental studies of molecular-motors. Here we describe the localized detection (Lard et al., Sci Rep 3:1092, 2013) and fast transport of actin filaments by myosin molecular-motors (Lard et al., Biosens Biolectron 48(0):145–152, 2013), inserted within nanostructures, as a method for biocomputation and molecular concentration. These results include extensive myosin driven concentration of actin filaments on a miniaturized detector, of relevance for use of molecular-motors in a diagnostics platform. Also, we discuss the local enhancement of the fluorescence signal of filaments, relevant for use in a biocomputation device where tracking of potentially thousands of motile objects is of primary significance. (Less)
- Abstract (Swedish)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/bb3ebf22-8427-4973-bd38-c7278f405bfb
- author
- Lard, Mercy
LU
; Ten Siethoff, L.
; Kumar, S.
; Persson, M.
; te Kronnie, G.
; Månsson, A.
and Linke, H.
LU
- organization
- publishing date
- 2015
- type
- Contribution to conference
- publication status
- published
- subject
- pages
- 1 pages
- conference name
- NATO Advanced Study Institute on Nano-Structures for Optics and Photonics: Optical Strategies for Enhancing Sensing, Imaging, Communication, and Energy Conversion
- conference location
- Erice, Italy
- conference dates
- 2013-07-04 - 2013-07-19
- external identifiers
-
- scopus:84921667061
- DOI
- 10.1007/978-94-017-9133-5_28
- language
- English
- LU publication?
- yes
- id
- bb3ebf22-8427-4973-bd38-c7278f405bfb
- date added to LUP
- 2016-04-12 12:25:00
- date last changed
- 2022-05-02 03:46:54
@misc{bb3ebf22-8427-4973-bd38-c7278f405bfb,
abstract = {{The interaction of self-propelled biological molecular-motors and cytoskeletal filaments holds relevance for a variety of applications such as biosensing, drug screening, diagnostics and biocomputation. The use of these systems for lab-on-a-chip biotechnology applications shows potential for replacement of microfluidic flow by active, molecular-motor driven transport of filaments. The ability to control, confine and detect motile objects in such a system is possible by development of nanostructured surfaces for on-chip applications and fundamental studies of molecular-motors. Here we describe the localized detection (Lard et al., Sci Rep 3:1092, 2013) and fast transport of actin filaments by myosin molecular-motors (Lard et al., Biosens Biolectron 48(0):145–152, 2013), inserted within nanostructures, as a method for biocomputation and molecular concentration. These results include extensive myosin driven concentration of actin filaments on a miniaturized detector, of relevance for use of molecular-motors in a diagnostics platform. Also, we discuss the local enhancement of the fluorescence signal of filaments, relevant for use in a biocomputation device where tracking of potentially thousands of motile objects is of primary significance.}},
author = {{Lard, Mercy and Ten Siethoff, L. and Kumar, S. and Persson, M. and te Kronnie, G. and Månsson, A. and Linke, H.}},
language = {{eng}},
pages = {{459--459}},
title = {{Nano-structuring for molecular motor control}},
url = {{http://dx.doi.org/10.1007/978-94-017-9133-5_28}},
doi = {{10.1007/978-94-017-9133-5_28}},
year = {{2015}},
}