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Image enhancements by CLAHE and gamma correction do not improve diagnostic accuracy in teledermoscopy: a retrospective cohort study

Kristensson, Hedvig LU ; Nätterdahl, Carolina LU orcid ; Persson, Bertil LU ; Saleh, Karim LU ; Kappelin, Johan LU ; Helkkula, Teo LU ; Johansson, Fredrik LU orcid ; Palmgren, Johan LU ; Lapins, Jan and Rados, Niki , et al. (2026) In Archives of Dermatological Research 318(1).
Abstract
Teledermoscopy (TDS) offers an efficient alternative to face-to-face assessment of suspicious skin lesions. Although diagnostic accuracy in TDS is relatively high, further improvement is desirable to reduce the risk of overlooked skin cancers and unnecessary interventions of benign lesions. Image enhancement (IE), i.e. digital modification of different parameters of an image, may potentially improve visualisation and thereby diagnostic accuracy. Several tools for IE were reviewed through two workshops and two were eventually selected for the study: Contrast Limited Adaptive Histogram Equalisation (CLAHE) for contrast enhancement and Gamma Correction for brightness adjustment. A retrospective randomized clinical study was performed in which... (More)
Teledermoscopy (TDS) offers an efficient alternative to face-to-face assessment of suspicious skin lesions. Although diagnostic accuracy in TDS is relatively high, further improvement is desirable to reduce the risk of overlooked skin cancers and unnecessary interventions of benign lesions. Image enhancement (IE), i.e. digital modification of different parameters of an image, may potentially improve visualisation and thereby diagnostic accuracy. Several tools for IE were reviewed through two workshops and two were eventually selected for the study: Contrast Limited Adaptive Histogram Equalisation (CLAHE) for contrast enhancement and Gamma Correction for brightness adjustment. A retrospective randomized clinical study was performed in which 1997 TDS cases were distributed to 13 assessors with varying dermoscopic experience, who assessed lesions either with access to IE-tools (IE-group) or without (control group). Diagnostic accuracy for malignant vs. benign and melanoma-group vs. non-melanoma-group lesions was compared using chi-square tests. A generalized linear mixed model (GLMM) with assessor as a random intercept and adjustment for image quality was applied to account for assessor-dependent variance. Management recommendations were analyzed using both graded intervention levels relative to a gold standard and a stricter harm–benefit framework, assessing inappropriately under-management of malignant and over-management of benign lesions. No significant differences were found between the groups regarding malignant/benign classification. For melanoma differentiation, specificity was slightly, but significantly lower in the IE group compared to the control group (86.3; 95% confidence interval (CI) 83.8–88.5 vs. 89.9%; 95% CI 87.6–91.8, respectively, p = 0.02) while sensitivity remained unchanged. GLMM analyses confirmed these findings. No significant differences were observed in appropriateness of management recommendations or diagnostic confidence. Use of the IE tools CLAHE and Gamma Correction did not improve diagnostic performance in TDS assessments. These findings do not support routine clinical use of these IE tools for the purpose of improving diagnostic assessment of skin lesions. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Dermatological Research
volume
318
issue
1
article number
59
publisher
Springer
ISSN
1432-069X
DOI
10.1007/s00403-025-04482-7
language
English
LU publication?
yes
id
bb4ca97e-56e9-4a67-9a74-b5516127dc8f
alternative location
https://link.springer.com/10.1007/s00403-025-04482-7
date added to LUP
2026-01-15 10:39:44
date last changed
2026-01-15 11:07:49
@article{bb4ca97e-56e9-4a67-9a74-b5516127dc8f,
  abstract     = {{Teledermoscopy (TDS) offers an efficient alternative to face-to-face assessment of suspicious skin lesions. Although diagnostic accuracy in TDS is relatively high, further improvement is desirable to reduce the risk of overlooked skin cancers and unnecessary interventions of benign lesions. Image enhancement (IE), i.e. digital modification of different parameters of an image, may potentially improve visualisation and thereby diagnostic accuracy. Several tools for IE were reviewed through two workshops and two were eventually selected for the study: Contrast Limited Adaptive Histogram Equalisation (CLAHE) for contrast enhancement and Gamma Correction for brightness adjustment. A retrospective randomized clinical study was performed in which 1997 TDS cases were distributed to 13 assessors with varying dermoscopic experience, who assessed lesions either with access to IE-tools (IE-group) or without (control group). Diagnostic accuracy for malignant vs. benign and melanoma-group vs. non-melanoma-group lesions was compared using chi-square tests. A generalized linear mixed model (GLMM) with assessor as a random intercept and adjustment for image quality was applied to account for assessor-dependent variance. Management recommendations were analyzed using both graded intervention levels relative to a gold standard and a stricter harm–benefit framework, assessing inappropriately under-management of malignant and over-management of benign lesions. No significant differences were found between the groups regarding malignant/benign classification. For melanoma differentiation, specificity was slightly, but significantly lower in the IE group compared to the control group (86.3; 95% confidence interval (CI) 83.8–88.5 vs. 89.9%; 95% CI 87.6–91.8, respectively, p = 0.02) while sensitivity remained unchanged. GLMM analyses confirmed these findings. No significant differences were observed in appropriateness of management recommendations or diagnostic confidence. Use of the IE tools CLAHE and Gamma Correction did not improve diagnostic performance in TDS assessments. These findings do not support routine clinical use of these IE tools for the purpose of improving diagnostic assessment of skin lesions.}},
  author       = {{Kristensson, Hedvig and Nätterdahl, Carolina and Persson, Bertil and Saleh, Karim and Kappelin, Johan and Helkkula, Teo and Johansson, Fredrik and Palmgren, Johan and Lapins, Jan and Rados, Niki and Ivert, Lina U. and Schultz, Karina and Nielsen, Kari and Ingvar, Åsa}},
  issn         = {{1432-069X}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{Springer}},
  series       = {{Archives of Dermatological Research}},
  title        = {{Image enhancements by CLAHE and gamma correction do not improve diagnostic accuracy in teledermoscopy: a retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1007/s00403-025-04482-7}},
  doi          = {{10.1007/s00403-025-04482-7}},
  volume       = {{318}},
  year         = {{2026}},
}