Natural killer cell activity and antibody-dependent cellular cytotoxicity in newborn infants
(1982) In Acta Paediatrica Scandinavica 71(3). p.431-436- Abstract
The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is... (More)
The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.
(Less)
- author
- Hallberg, A and Malmström, P LU
- organization
- publishing date
- 1982
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Antibody-Dependent Cell Cytotoxicity, Cytotoxicity, Immunologic, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Killer Cells, Natural/immunology, Lymphocytes/immunology, Male
- in
- Acta Paediatrica Scandinavica
- volume
- 71
- issue
- 3
- pages
- 431 - 436
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0020050832
- pmid:7136657
- ISSN
- 0001-656X
- DOI
- 10.1111/j.1651-2227.1982.tb09447.x
- language
- English
- LU publication?
- yes
- id
- bb7c62b5-ba32-42dd-b587-9cf7fa24f113
- date added to LUP
- 2022-02-24 23:09:49
- date last changed
- 2024-01-06 12:37:46
@article{bb7c62b5-ba32-42dd-b587-9cf7fa24f113,
abstract = {{<p>The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.</p>}},
author = {{Hallberg, A and Malmström, P}},
issn = {{0001-656X}},
keywords = {{Adult; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Killer Cells, Natural/immunology; Lymphocytes/immunology; Male}},
language = {{eng}},
number = {{3}},
pages = {{431--436}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica Scandinavica}},
title = {{Natural killer cell activity and antibody-dependent cellular cytotoxicity in newborn infants}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.1982.tb09447.x}},
doi = {{10.1111/j.1651-2227.1982.tb09447.x}},
volume = {{71}},
year = {{1982}},
}