Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age
(1992) In Muscle and Nerve 15(3). p.404-409- Abstract
- The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied... (More)
- The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied by a functional development of the fiber population: the proportion of type 2 fibers increases significantly from the age of 5 (approx. 35%) to the age of 20 (approx. 50%), which, in the absence of any discernible effect on the total number of fibers, is most likely caused by a transformation of type 1 to type 2 fibers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106711
- author
- Lexell, Jan LU ; Sjöström, Michael ; Nordlund, Ann-Sofie and Taylor, Charles C
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aging, histocytochemistry, growth, muscles, physiological adaptation
- in
- Muscle and Nerve
- volume
- 15
- issue
- 3
- pages
- 404 - 409
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:1557091
- scopus:0026606708
- pmid:1557091
- ISSN
- 0148-639X
- DOI
- 10.1002/mus.880150323
- language
- English
- LU publication?
- no
- id
- bb81405e-1e24-485a-883a-1670e2bae9cc (old id 1106711)
- date added to LUP
- 2016-04-01 11:59:22
- date last changed
- 2021-09-26 04:45:59
@article{bb81405e-1e24-485a-883a-1670e2bae9cc,
abstract = {{The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied by a functional development of the fiber population: the proportion of type 2 fibers increases significantly from the age of 5 (approx. 35%) to the age of 20 (approx. 50%), which, in the absence of any discernible effect on the total number of fibers, is most likely caused by a transformation of type 1 to type 2 fibers.}},
author = {{Lexell, Jan and Sjöström, Michael and Nordlund, Ann-Sofie and Taylor, Charles C}},
issn = {{0148-639X}},
keywords = {{aging; histocytochemistry; growth; muscles; physiological adaptation}},
language = {{eng}},
number = {{3}},
pages = {{404--409}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Muscle and Nerve}},
title = {{Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age}},
url = {{http://dx.doi.org/10.1002/mus.880150323}},
doi = {{10.1002/mus.880150323}},
volume = {{15}},
year = {{1992}},
}