Family patterns of arterial stiffness across three generations in the Malmö Offspring Study
(2020) In Journal of Hypertension 38(3). p.474-480- Abstract
Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all... (More)
Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all offsprings. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were stratified into quartiles by c-f PWV. Offspring c-f PWV means were compared with one-way ANOVA analyses. Multiple regression analyses were adjusted for age, sex, BMI, SBP and fasting glucose. Bonferroni corrections were used.Results:c-f PWV in offsprings was positively correlated with c-f PWV in parents (r = 0.26, P < 0.001) and in grandparents (r = 0.29, P < 0.001). Parents with high c-f PWV had offspring with significantly higher means of c-f PWV.Conclusion:A measure of aortic stiffness (c-f PWV) is positively correlated across three related generations in this population-based study.
(Less)
- author
- Rosberg, Erik P. and Nilsson, Peter M. LU
- organization
- publishing date
- 2020-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arterial stiffness, family, generation, heredity, offspring, pulse wave velocity
- in
- Journal of Hypertension
- volume
- 38
- issue
- 3
- pages
- 7 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:31725074
- scopus:85079086331
- ISSN
- 0263-6352
- DOI
- 10.1097/HJH.0000000000002293
- language
- English
- LU publication?
- yes
- id
- bbc455f1-4d07-4fff-8ae6-a20ff9a63590
- date added to LUP
- 2021-01-12 14:26:38
- date last changed
- 2024-09-19 14:34:42
@article{bbc455f1-4d07-4fff-8ae6-a20ff9a63590, abstract = {{<p>Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all offsprings. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were stratified into quartiles by c-f PWV. Offspring c-f PWV means were compared with one-way ANOVA analyses. Multiple regression analyses were adjusted for age, sex, BMI, SBP and fasting glucose. Bonferroni corrections were used.Results:c-f PWV in offsprings was positively correlated with c-f PWV in parents (r = 0.26, P < 0.001) and in grandparents (r = 0.29, P < 0.001). Parents with high c-f PWV had offspring with significantly higher means of c-f PWV.Conclusion:A measure of aortic stiffness (c-f PWV) is positively correlated across three related generations in this population-based study.</p>}}, author = {{Rosberg, Erik P. and Nilsson, Peter M.}}, issn = {{0263-6352}}, keywords = {{arterial stiffness; family; generation; heredity; offspring; pulse wave velocity}}, language = {{eng}}, number = {{3}}, pages = {{474--480}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Hypertension}}, title = {{Family patterns of arterial stiffness across three generations in the Malmö Offspring Study}}, url = {{http://dx.doi.org/10.1097/HJH.0000000000002293}}, doi = {{10.1097/HJH.0000000000002293}}, volume = {{38}}, year = {{2020}}, }