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Family patterns of arterial stiffness across three generations in the Malmö Offspring Study

Rosberg, Erik P. and Nilsson, Peter M. LU (2020) In Journal of Hypertension 38(3). p.474-480
Abstract

Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all... (More)

Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all offsprings. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were stratified into quartiles by c-f PWV. Offspring c-f PWV means were compared with one-way ANOVA analyses. Multiple regression analyses were adjusted for age, sex, BMI, SBP and fasting glucose. Bonferroni corrections were used.Results:c-f PWV in offsprings was positively correlated with c-f PWV in parents (r = 0.26, P < 0.001) and in grandparents (r = 0.29, P < 0.001). Parents with high c-f PWV had offspring with significantly higher means of c-f PWV.Conclusion:A measure of aortic stiffness (c-f PWV) is positively correlated across three related generations in this population-based study.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial stiffness, family, generation, heredity, offspring, pulse wave velocity
in
Journal of Hypertension
volume
38
issue
3
pages
7 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85079086331
  • pmid:31725074
ISSN
0263-6352
DOI
10.1097/HJH.0000000000002293
language
English
LU publication?
yes
id
bbc455f1-4d07-4fff-8ae6-a20ff9a63590
date added to LUP
2021-01-12 14:26:38
date last changed
2025-10-14 09:19:22
@article{bbc455f1-4d07-4fff-8ae6-a20ff9a63590,
  abstract     = {{<p>Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics.Aim:To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV.Methods:In all, 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included. c-f PWV was measured (Sphygmocor) in grandparents and in all offsprings. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were stratified into quartiles by c-f PWV. Offspring c-f PWV means were compared with one-way ANOVA analyses. Multiple regression analyses were adjusted for age, sex, BMI, SBP and fasting glucose. Bonferroni corrections were used.Results:c-f PWV in offsprings was positively correlated with c-f PWV in parents (r = 0.26, P &lt; 0.001) and in grandparents (r = 0.29, P &lt; 0.001). Parents with high c-f PWV had offspring with significantly higher means of c-f PWV.Conclusion:A measure of aortic stiffness (c-f PWV) is positively correlated across three related generations in this population-based study.</p>}},
  author       = {{Rosberg, Erik P. and Nilsson, Peter M.}},
  issn         = {{0263-6352}},
  keywords     = {{arterial stiffness; family; generation; heredity; offspring; pulse wave velocity}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{474--480}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{Family patterns of arterial stiffness across three generations in the Malmö Offspring Study}},
  url          = {{http://dx.doi.org/10.1097/HJH.0000000000002293}},
  doi          = {{10.1097/HJH.0000000000002293}},
  volume       = {{38}},
  year         = {{2020}},
}