A lower eGFRcystatin C/eGFRcreatinine ratio is associated with greater cardiovascular risk (higher Framingham Risk Score) in Chinese patients with newly diagnosed type 2 diabetes mellitus
(2024) In Renal failure 46(2).- Abstract
Background: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. Shrunken pore syndrome (SPS) is defined as eGFRcystatin C/eGFRcreatinine ratio <0.70 and predicts high CVD mortality. The Framingham Risk Score (FRS) is used to estimate an individual’s 10-year CVD risk. This study investigated the association between FRS and eGFRcystatin C/eGFRcreatinine ratio in T2DM patients. Methods: Patients aged 18-80 years who were newly diagnosed with T2DM were included in this retrospective study. Ordinal logistic regression analysis was used to investigate the association between risk factors of T2DM and FRS. A Generalized Linear Model was used... (More)
Background: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. Shrunken pore syndrome (SPS) is defined as eGFRcystatin C/eGFRcreatinine ratio <0.70 and predicts high CVD mortality. The Framingham Risk Score (FRS) is used to estimate an individual’s 10-year CVD risk. This study investigated the association between FRS and eGFRcystatin C/eGFRcreatinine ratio in T2DM patients. Methods: Patients aged 18-80 years who were newly diagnosed with T2DM were included in this retrospective study. Ordinal logistic regression analysis was used to investigate the association between risk factors of T2DM and FRS. A Generalized Linear Model was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: There were 270 patients included in the study. Only 27 patients (10%) met the diagnostic criteria of SPS. Ordinal logistic regression analysis showed that SPS was not correlated with FRS risk (OR = 1.99, 95%CI = 0.94–4.23, p = 0.07), whereas eGFRcystatin C/eGFRcreatinine (OR = 0.86, 95%CI = 0.77–0.97, p = 0.01) showed a significant negative association with FRS risk. Compared with eGFRcystatin C/eGFRcreatinine>0.85, eGFRcystatin C/eGFRcreatinine≤0.85 increased FRS risk (OR = 1.95, 95%CI = 1.18–3.21, p < 0.01). After adjustment for confounding factors, increased eGFRcystatin C/eGFRcreatinine ratio was associated with decreased FRS risk when considered as a continuous variable (OR = 0.87, 95%CI = 0.77–0.99, p = 0.03). The FRS risk in patients with eGFRcystatin C/eGFRcreatinine≤0.85 is 1.86 times higher than that in patients with eGFRcystatin C/eGFRcreatinine>0.85 (OR = 1.86, 95%CI = 1.08–3.21, p = 0.03). Conclusions: In the current study, no significant association between SPS and FRS was identified. However, lower eGFRcystatin C/eGFRcreatinine and eGFRcystatin C/eGFRcreatinine≤0.85 were associated with a significantly increased CVD risk in T2DM.
(Less)
- author
- Yang, Yan ; Yang, Bixia ; Zhao, Shizhu ; Liu, Shusu ; Zhou, Hua ; Xu, Ning LU and Yang, Min
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- eGFR, framingham risk score, shrunken pore syndrome, Type 2 diabetes mellitus
- in
- Renal failure
- volume
- 46
- issue
- 2
- article number
- 2346267
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:38905298
- scopus:85196510629
- ISSN
- 0886-022X
- DOI
- 10.1080/0886022X.2024.2346267
- language
- English
- LU publication?
- yes
- id
- bbd547cb-ba43-492c-aeca-c3638a1bb9d2
- date added to LUP
- 2024-09-02 12:11:19
- date last changed
- 2024-09-03 03:00:13
@article{bbd547cb-ba43-492c-aeca-c3638a1bb9d2,
abstract = {{<p>Background: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. Shrunken pore syndrome (SPS) is defined as eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> ratio <0.70 and predicts high CVD mortality. The Framingham Risk Score (FRS) is used to estimate an individual’s 10-year CVD risk. This study investigated the association between FRS and eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> ratio in T2DM patients. Methods: Patients aged 18-80 years who were newly diagnosed with T2DM were included in this retrospective study. Ordinal logistic regression analysis was used to investigate the association between risk factors of T2DM and FRS. A Generalized Linear Model was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: There were 270 patients included in the study. Only 27 patients (10%) met the diagnostic criteria of SPS. Ordinal logistic regression analysis showed that SPS was not correlated with FRS risk (OR = 1.99, 95%CI = 0.94–4.23, p = 0.07), whereas eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> (OR = 0.86, 95%CI = 0.77–0.97, p = 0.01) showed a significant negative association with FRS risk. Compared with eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub>>0.85, eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub>≤0.85 increased FRS risk (OR = 1.95, 95%CI = 1.18–3.21, p < 0.01). After adjustment for confounding factors, increased eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> ratio was associated with decreased FRS risk when considered as a continuous variable (OR = 0.87, 95%CI = 0.77–0.99, p = 0.03). The FRS risk in patients with eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub>≤0.85 is 1.86 times higher than that in patients with eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub>>0.85 (OR = 1.86, 95%CI = 1.08–3.21, p = 0.03). Conclusions: In the current study, no significant association between SPS and FRS was identified. However, lower eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> and eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub>≤0.85 were associated with a significantly increased CVD risk in T2DM.</p>}},
author = {{Yang, Yan and Yang, Bixia and Zhao, Shizhu and Liu, Shusu and Zhou, Hua and Xu, Ning and Yang, Min}},
issn = {{0886-022X}},
keywords = {{eGFR; framingham risk score; shrunken pore syndrome; Type 2 diabetes mellitus}},
language = {{eng}},
number = {{2}},
publisher = {{Taylor & Francis}},
series = {{Renal failure}},
title = {{A lower eGFR<sub>cystatin C</sub>/eGFR<sub>creatinine</sub> ratio is associated with greater cardiovascular risk (higher Framingham Risk Score) in Chinese patients with newly diagnosed type 2 diabetes mellitus}},
url = {{http://dx.doi.org/10.1080/0886022X.2024.2346267}},
doi = {{10.1080/0886022X.2024.2346267}},
volume = {{46}},
year = {{2024}},
}