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Working memory training decreases hippocampal neurogenesis.

Mohapel, Paul LU ; Orre, Karin LU ; Brundin, Patrik LU and Frielingsdorf, Helena LU (2006) In Neuroscience 142(3). p.609-613
Abstract
The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a... (More)
The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
corticosterone, reference memory, BrdU, Morris water maze, working memory
in
Neuroscience
volume
142
issue
3
pages
609 - 613
publisher
Elsevier
external identifiers
  • wos:000241530600001
  • scopus:33749244443
  • pmid:16962715
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2006.07.033
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Molecular Psychiatry Unit (013024100), Wallenberg Neuroscience Centre, Lund (0131000110)
id
bbf4f79d-5530-4f50-bab2-9b3334f57d6f (old id 161116)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16962715&dopt=Abstract
date added to LUP
2016-04-01 11:47:24
date last changed
2020-01-12 08:36:49
@article{bbf4f79d-5530-4f50-bab2-9b3334f57d6f,
  abstract     = {The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress.},
  author       = {Mohapel, Paul and Orre, Karin and Brundin, Patrik and Frielingsdorf, Helena},
  issn         = {1873-7544},
  language     = {eng},
  number       = {3},
  pages        = {609--613},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Working memory training decreases hippocampal neurogenesis.},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2006.07.033},
  doi          = {10.1016/j.neuroscience.2006.07.033},
  volume       = {142},
  year         = {2006},
}