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Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.

Aso, Ester; Martinsson, Isak LU ; Appelhans, Dietmar ; Effenberg, C; Benseny-Cases, Núria; Gouras, Gunnar LU ; Ferrer, Isidre and Klementieva, Oxana LU (2019) In Nanomedicine: Nanotechnology, Biology, and Medicine p.198-209
Abstract
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood brain barrier in vivo. Therefore, we suggest that a maltose-histidine shell can be used to improve... (More)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood brain barrier in vivo. Therefore, we suggest that a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood brain barrier of dendrimers. Moreover, G4HisMal demonstrated properties for synapse and memory protection when administered to Alzheimer disease transgenic mice. Therefore, G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanomedicine: Nanotechnology, Biology, and Medicine
pages
198 - 209
publisher
Elsevier
external identifiers
  • scopus:85062302565
ISSN
1549-9642
DOI
10.1016/j.nano.2019.01.010
language
English
LU publication?
yes
id
bc1ce5f6-df67-423d-b362-f6d7c54b628d
date added to LUP
2019-02-15 23:51:20
date last changed
2019-03-17 05:13:00
@article{bc1ce5f6-df67-423d-b362-f6d7c54b628d,
  abstract     = {Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood brain barrier in vivo. Therefore, we suggest that a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood brain barrier of dendrimers. Moreover, G4HisMal demonstrated properties for synapse and memory protection when administered to Alzheimer disease transgenic mice. Therefore, G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection.},
  author       = {Aso, Ester and Martinsson, Isak and Appelhans, Dietmar  and Effenberg, C and Benseny-Cases, Núria and Gouras, Gunnar and Ferrer, Isidre  and Klementieva, Oxana},
  issn         = {1549-9642},
  language     = {eng},
  pages        = {198--209},
  publisher    = {Elsevier},
  series       = {Nanomedicine: Nanotechnology, Biology, and Medicine},
  title        = {Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.},
  url          = {http://dx.doi.org/10.1016/j.nano.2019.01.010},
  year         = {2019},
}