Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation
(2010) In ACS Chemical Neuroscience 1(4). p.279-287- Abstract
- The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the... (More)
- The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1617167
- author
- Cabaleiro-Lago, Celia ; Quinlan-Pluck, Fiona ; Lynch, Iseult ; Dawson, Kenneth A. and Linse, Sara LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amyloid, aggregation kinetics, nanoparticles
- in
- ACS Chemical Neuroscience
- volume
- 1
- issue
- 4
- pages
- 279 - 287
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000277981200005
- scopus:77951681963
- pmid:22778827
- ISSN
- 1948-7193
- DOI
- 10.1021/cn900027u
- language
- English
- LU publication?
- yes
- id
- bc27f325-840b-4f15-8b5b-9fdc1b7620f8 (old id 1617167)
- date added to LUP
- 2016-04-01 14:24:49
- date last changed
- 2023-11-13 07:17:56
@article{bc27f325-840b-4f15-8b5b-9fdc1b7620f8,
abstract = {{The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants.}},
author = {{Cabaleiro-Lago, Celia and Quinlan-Pluck, Fiona and Lynch, Iseult and Dawson, Kenneth A. and Linse, Sara}},
issn = {{1948-7193}},
keywords = {{Amyloid; aggregation kinetics; nanoparticles}},
language = {{eng}},
number = {{4}},
pages = {{279--287}},
publisher = {{The American Chemical Society (ACS)}},
series = {{ACS Chemical Neuroscience}},
title = {{Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation}},
url = {{http://dx.doi.org/10.1021/cn900027u}},
doi = {{10.1021/cn900027u}},
volume = {{1}},
year = {{2010}},
}