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Structural insights into eukaryotic aquaporin regulation

Törnroth-Horsefield, Susanna LU ; Hedfalk, Kristina; Fischer, Gerhard; Lindkvist-Petersson, Karin LU and Neutze, Richard (2010) In FEBS Letters 584(12). p.2580-2588
Abstract

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies... (More)

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies are described. Basic structural themes reoccur, illustrating how the problem of regulation in diverse biological contexts builds upon a limited set of possible solutions.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Aquaporin, Membrane protein structural biology, X-ray diffraction
in
FEBS Letters
volume
584
issue
12
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:77953578957
ISSN
0014-5793
DOI
10.1016/j.febslet.2010.04.037
language
English
LU publication?
no
id
bc37d4d9-4ff3-4257-9b81-6eee84f16532
date added to LUP
2017-02-14 16:27:31
date last changed
2018-09-09 04:48:17
@article{bc37d4d9-4ff3-4257-9b81-6eee84f16532,
  abstract     = {<p>Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies are described. Basic structural themes reoccur, illustrating how the problem of regulation in diverse biological contexts builds upon a limited set of possible solutions.</p>},
  author       = {Törnroth-Horsefield, Susanna and Hedfalk, Kristina and Fischer, Gerhard and Lindkvist-Petersson, Karin and Neutze, Richard},
  issn         = {0014-5793},
  keyword      = {Aquaporin,Membrane protein structural biology,X-ray diffraction},
  language     = {eng},
  number       = {12},
  pages        = {2580--2588},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {Structural insights into eukaryotic aquaporin regulation},
  url          = {http://dx.doi.org/10.1016/j.febslet.2010.04.037},
  volume       = {584},
  year         = {2010},
}