Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)
(2011) In International Journal of Cancer 128(11). p.2695-2708- Abstract
- Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference,... (More)
- Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted. (Less)
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https://lup.lub.lu.se/record/1965643
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- urothelial cell carcinomas, bladder cancer, fluid, EPIC
- in
- International Journal of Cancer
- volume
- 128
- issue
- 11
- pages
- 2695 - 2708
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000289372000020
- scopus:79953309327
- pmid:20715171
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.25592
- language
- English
- LU publication?
- yes
- id
- bc9ea6fa-f7b3-498a-a53f-d36cca921fdc (old id 1965643)
- date added to LUP
- 2016-04-01 10:25:11
- date last changed
- 2022-04-27 21:51:55
@article{bc9ea6fa-f7b3-498a-a53f-d36cca921fdc,
abstract = {{Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.}},
author = {{Ros, Martine M. and Bueno-de-Mesquita, H. B. Bas and Buchner, Frederike L. and Aben, Katja K. H. and Kampman, Ellen and Egevad, Lars and Overvad, Kim and Tjonneland, Anne and Roswall, Nina and Clavel-Chapelon, Francoise and Kaaks, Rudolf and Chang-Claude, Jenny and Boeing, Heiner and Weikert, Steffen and Trichopoulou, Antonia and Orfanos, Philippos and Stasinopulou, Georgia and Saieva, Calogero and Krogh, Vittorio and Vineis, Paolo and Tumino, Rosario and Mattiello, Amalia and Peeters, Petra H. M. and van Duijnhoven, Franzel J. B. and Lund, Eiliv and Gram, Inger T. and Chirlaque, Maria D. and Barricarte, Aurelio and Rodriguez, Laudina and Molina, Esther and Gonzalez, Carlos and Dorronsoro, Miren and Manjer, Jonas and Ehrnström, Roy and Ljungberg, Borje and Allen, Naomi E. and Roddam, Andrew W. and Khaw, Kay-Tee and Wareham, Nick and Boffetta, Paolo and Slimani, Nadia and Michaud, Dominique S. and Kiemeney, Lambertus A. L. M. and Riboli, Elio}},
issn = {{0020-7136}},
keywords = {{urothelial cell carcinomas; bladder cancer; fluid; EPIC}},
language = {{eng}},
number = {{11}},
pages = {{2695--2708}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)}},
url = {{http://dx.doi.org/10.1002/ijc.25592}},
doi = {{10.1002/ijc.25592}},
volume = {{128}},
year = {{2011}},
}