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RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8

Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M. LU ; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L. and La Cava, S., et al. (2016) In Food and Chemical Toxicology 97. p.101-109
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed... (More)

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

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publication status
published
subject
keywords
Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
101 - 109
publisher
Elsevier
external identifiers
  • scopus:84997272193
ISSN
0278-6915
DOI
10.1016/j.fct.2016.07.031
language
English
LU publication?
no
id
bce46ace-1035-459d-9331-bc78ed75b277
date added to LUP
2016-12-12 11:46:47
date last changed
2017-05-05 13:44:28
@article{bce46ace-1035-459d-9331-bc78ed75b277,
  abstract     = {<p>The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE &gt; 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.</p>},
  author       = {Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Miyachi, Y. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.},
  issn         = {0278-6915},
  keyword      = {Developmental and reproductive toxicity,Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose,Skin sensitization},
  language     = {eng},
  month        = {11},
  pages        = {101--109},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.07.031},
  volume       = {97},
  year         = {2016},
}