Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls
(2020) In Frontiers in Psychiatry 11.- Abstract
Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these two components in violent, inpatient MDOs. Here, we examined self-reported trait disinhibition, experimentally assessed response inhibition, and NoGo N2 and P3 amplitude and latency in male, violent MDOs (N = 27) and healthy controls (N = 20). MDOs had a higher degree of trait disinhibition, reduced NoGo P3 amplitude, and delayed NoGo P3 latency... (More)
Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these two components in violent, inpatient MDOs. Here, we examined self-reported trait disinhibition, experimentally assessed response inhibition, and NoGo N2 and P3 amplitude and latency in male, violent MDOs (N = 27) and healthy controls (N = 20). MDOs had a higher degree of trait disinhibition, reduced NoGo P3 amplitude, and delayed NoGo P3 latency compared to controls. The reduced NoGo P3 amplitude and delayed NoGo P3 latency in MDOs may stem from deficits during monitoring or evaluation of behavior. NoGo P3 latency was associated with increased trait disinhibition in the whole sample, suggesting that trait disinhibition may be associated with reduced neural efficiency during later stages of outcome monitoring or evaluation. Findings for NoGo N2 amplitude and latency were small and non-robust. With several limitations in mind, this is the first study to demonstrate attenuated NoGo P3 amplitude and delayed NoGo P3 latency in violent, inpatient MDOs compared to healthy controls.
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- author
- Delfin, Carl LU ; Ruzich, Emily ; Wallinius, Märta LU ; Björnsdotter, Malin and Andiné, Peter
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ERP, event-related potential, forensic psychiatry, mentally disordered offenders, N2, P3, trait disinhibition
- in
- Frontiers in Psychiatry
- volume
- 11
- article number
- 577491
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85098105841
- pmid:33362599
- ISSN
- 1664-0640
- DOI
- 10.3389/fpsyt.2020.577491
- language
- English
- LU publication?
- yes
- id
- bcf2d79a-3a27-4773-9fd5-4f01f8d2392e
- date added to LUP
- 2021-01-05 12:50:39
- date last changed
- 2024-05-30 02:39:54
@article{bcf2d79a-3a27-4773-9fd5-4f01f8d2392e,
abstract = {{<p>Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these two components in violent, inpatient MDOs. Here, we examined self-reported trait disinhibition, experimentally assessed response inhibition, and NoGo N2 and P3 amplitude and latency in male, violent MDOs (N = 27) and healthy controls (N = 20). MDOs had a higher degree of trait disinhibition, reduced NoGo P3 amplitude, and delayed NoGo P3 latency compared to controls. The reduced NoGo P3 amplitude and delayed NoGo P3 latency in MDOs may stem from deficits during monitoring or evaluation of behavior. NoGo P3 latency was associated with increased trait disinhibition in the whole sample, suggesting that trait disinhibition may be associated with reduced neural efficiency during later stages of outcome monitoring or evaluation. Findings for NoGo N2 amplitude and latency were small and non-robust. With several limitations in mind, this is the first study to demonstrate attenuated NoGo P3 amplitude and delayed NoGo P3 latency in violent, inpatient MDOs compared to healthy controls.</p>}},
author = {{Delfin, Carl and Ruzich, Emily and Wallinius, Märta and Björnsdotter, Malin and Andiné, Peter}},
issn = {{1664-0640}},
keywords = {{ERP; event-related potential; forensic psychiatry; mentally disordered offenders; N2; P3; trait disinhibition}},
language = {{eng}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Psychiatry}},
title = {{Trait Disinhibition and NoGo Event-Related Potentials in Violent Mentally Disordered Offenders and Healthy Controls}},
url = {{http://dx.doi.org/10.3389/fpsyt.2020.577491}},
doi = {{10.3389/fpsyt.2020.577491}},
volume = {{11}},
year = {{2020}},
}