A prospective double blind randomized study comparing the need for blood transfusion with terlipressin or a placebo during early excision and grafting of burns
(2004) In Burns 30(3). p.236-240- Abstract
- Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients... (More)
- Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients exposed to terlipressin were transfused with eleven units of packed red blood cells. Seven out of 13 patients crossed over from placebo to terlipressin (late terlipressin) were transfused with 17 units of blood. Eight out of 17 patients exposed to the placebo were transfused with 22 units of blood (P < 0.05). Graft healing was 1055 +/- 609 cm(2) out of 1452 +/- 1811 cm(2) in terlipressin and 914 +/- 633 cm(2) out of 1288 720 cm 2 in the placebo group (n.s.). Conclusion: Terlipressin reduced the need for blood transfusion by a factor of 2.5 compared to a placebo without impairment of graft healing. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/281056
- author
- Mzezewa, S ; Jonsson, K ; Åberg, Magnus LU ; Sjoberg, T and Salemark, Lars LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood loss, burns, early excision, terlipressin
- in
- Burns
- volume
- 30
- issue
- 3
- pages
- 236 - 240
- publisher
- Elsevier
- external identifiers
-
- wos:000220969800006
- pmid:15082350
- scopus:1842735259
- ISSN
- 0305-4179
- DOI
- 10.1016/j.burns.2003.11.004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Otorhinolaryngology (Lund) (013044000)
- id
- bcf41376-5878-47c4-bd77-2c4162c9544a (old id 281056)
- date added to LUP
- 2016-04-01 11:57:12
- date last changed
- 2022-03-28 18:06:41
@article{bcf41376-5878-47c4-bd77-2c4162c9544a,
abstract = {{Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients exposed to terlipressin were transfused with eleven units of packed red blood cells. Seven out of 13 patients crossed over from placebo to terlipressin (late terlipressin) were transfused with 17 units of blood. Eight out of 17 patients exposed to the placebo were transfused with 22 units of blood (P < 0.05). Graft healing was 1055 +/- 609 cm(2) out of 1452 +/- 1811 cm(2) in terlipressin and 914 +/- 633 cm(2) out of 1288 720 cm 2 in the placebo group (n.s.). Conclusion: Terlipressin reduced the need for blood transfusion by a factor of 2.5 compared to a placebo without impairment of graft healing.}},
author = {{Mzezewa, S and Jonsson, K and Åberg, Magnus and Sjoberg, T and Salemark, Lars}},
issn = {{0305-4179}},
keywords = {{blood loss; burns; early excision; terlipressin}},
language = {{eng}},
number = {{3}},
pages = {{236--240}},
publisher = {{Elsevier}},
series = {{Burns}},
title = {{A prospective double blind randomized study comparing the need for blood transfusion with terlipressin or a placebo during early excision and grafting of burns}},
url = {{http://dx.doi.org/10.1016/j.burns.2003.11.004}},
doi = {{10.1016/j.burns.2003.11.004}},
volume = {{30}},
year = {{2004}},
}