3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects
Forni, Matilde LU ; Thorbergsson, Palmi Thor LU ; Thelin, Jonas LU
and Schouenborg, Jens
LU
(2021)
In Science Advances
7(41).
- Abstract
The lack of satisfactory treatment for persistent pain profoundly impairs the quality of life for many patients. Stimulation of brainstem pain control systems can trigger powerful analgesia, but their complex network organization frequently prevents separation of analgesia from side effects. To overcome this long-standing challenge, we developed a biocompatible gelatin-embedded cluster of ultrathin microelectrodes that enables fine-tuned, high-definition three-dimensional stimulation in periaqueductal gray/dorsal raphe nucleus in awake rats. Analgesia was assessed from both motor reactions and intracortical signals, corresponding to pain-related signals in humans. We could select an individual-specific subset of microelectrodes in each... (More)
The lack of satisfactory treatment for persistent pain profoundly impairs the quality of life for many patients. Stimulation of brainstem pain control systems can trigger powerful analgesia, but their complex network organization frequently prevents separation of analgesia from side effects. To overcome this long-standing challenge, we developed a biocompatible gelatin-embedded cluster of ultrathin microelectrodes that enables fine-tuned, high-definition three-dimensional stimulation in periaqueductal gray/dorsal raphe nucleus in awake rats. Analgesia was assessed from both motor reactions and intracortical signals, corresponding to pain-related signals in humans. We could select an individual-specific subset of microelectrodes in each animal that reliably provided strong pain inhibition during normal and hyperalgesia conditions, without noticeable behavioral side effects. Gait, spontaneous cortical activity at rest, and cortical tactile responses were minimally affected, indicating a highly selective action. In conclusion, our developed biocompatible microelectrode cluster and stimulation paradigm reliably enabled powerful, fine-tuned, and selective analgesia without noticeable side effects.
(Less)
- author
- Forni, Matilde
LU
; Thorbergsson, Palmi Thor
LU
; Thelin, Jonas
LU
and Schouenborg, Jens
LU
- organization
- publishing date
- 2021-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science Advances
- volume
- 7
- issue
- 41
- article number
- abj2847
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:34623922
- scopus:85116828291
- ISSN
- 2375-2548
- DOI
- 10.1126/sciadv.abj2847
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors.
- id
- bcf4bd8e-2148-4ebe-84c0-25c6c1dd19de
- date added to LUP
- 2021-11-12 12:55:32
- date last changed
- 2024-06-01 19:24:55
@article{bcf4bd8e-2148-4ebe-84c0-25c6c1dd19de,
abstract = {{<p>The lack of satisfactory treatment for persistent pain profoundly impairs the quality of life for many patients. Stimulation of brainstem pain control systems can trigger powerful analgesia, but their complex network organization frequently prevents separation of analgesia from side effects. To overcome this long-standing challenge, we developed a biocompatible gelatin-embedded cluster of ultrathin microelectrodes that enables fine-tuned, high-definition three-dimensional stimulation in periaqueductal gray/dorsal raphe nucleus in awake rats. Analgesia was assessed from both motor reactions and intracortical signals, corresponding to pain-related signals in humans. We could select an individual-specific subset of microelectrodes in each animal that reliably provided strong pain inhibition during normal and hyperalgesia conditions, without noticeable behavioral side effects. Gait, spontaneous cortical activity at rest, and cortical tactile responses were minimally affected, indicating a highly selective action. In conclusion, our developed biocompatible microelectrode cluster and stimulation paradigm reliably enabled powerful, fine-tuned, and selective analgesia without noticeable side effects. </p>}},
author = {{Forni, Matilde and Thorbergsson, Palmi Thor and Thelin, Jonas and Schouenborg, Jens}},
issn = {{2375-2548}},
language = {{eng}},
number = {{41}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science Advances}},
title = {{3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects}},
url = {{http://dx.doi.org/10.1126/sciadv.abj2847}},
doi = {{10.1126/sciadv.abj2847}},
volume = {{7}},
year = {{2021}},
}