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Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and conditioned place aversion

Spina, Liliana; Longoni, Rosanna; Rosas, Michela; Collu, Maria; Peana, Alessandra T; Espa, Elena LU ; Kasture, Sanjay; Cotti, Elisabetta and Acquas, Elio (2015) In Journal of Psychopharmacology 29(11). p.9-1191
Abstract

Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To this end male CD-1 mice were conditioned under two distinct schedules: in backward conditioning experiments ethanol was administered before mice were placed in the conditioning apparatus (CPP) while, in forward conditioning experiments, ethanol was administered immediately after removing mice from the apparatus (CPA). Following these schedules,... (More)

Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To this end male CD-1 mice were conditioned under two distinct schedules: in backward conditioning experiments ethanol was administered before mice were placed in the conditioning apparatus (CPP) while, in forward conditioning experiments, ethanol was administered immediately after removing mice from the apparatus (CPA). Following these schedules, mice developed significant CPP and CPA, respectively. Administration of WSE significantly impaired both the acquisition (50 and 100 mg/kg) and the expression (50 mg/kg) of CPP and CPA without affecting spatial memory (50 mg/kg), as determined by a two-trial memory recognition task. Overall, the study highlights the ability of WSE to interfere with both positive and negative motivational properties of ethanol and suggests that the effects of WSE may target both ethanol's motivational properties and underpinning associative learning mechanisms. In conclusion, these results cast new light on Withania somnifera as an agent potentially useful to counteract distinct aspects of ethanol effects.

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publishing date
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publication status
published
keywords
Animals, Avoidance Learning, Conditioning (Psychology), Dose-Response Relationship, Drug, Ethanol, Male, Methanol, Mice, Plant Extracts, Plant Roots, Recognition (Psychology), Reward, Self Administration, Withania, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of Psychopharmacology
volume
29
issue
11
pages
9 pages
publisher
SAGE Publications Inc.
external identifiers
  • scopus:84945912014
ISSN
1461-7285
DOI
10.1177/0269881115600132
language
English
LU publication?
no
id
bd36706f-3904-44d9-823b-bd6bc7b90835
date added to LUP
2017-03-29 21:40:14
date last changed
2017-05-28 04:58:57
@article{bd36706f-3904-44d9-823b-bd6bc7b90835,
  abstract     = {<p>Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To this end male CD-1 mice were conditioned under two distinct schedules: in backward conditioning experiments ethanol was administered before mice were placed in the conditioning apparatus (CPP) while, in forward conditioning experiments, ethanol was administered immediately after removing mice from the apparatus (CPA). Following these schedules, mice developed significant CPP and CPA, respectively. Administration of WSE significantly impaired both the acquisition (50 and 100 mg/kg) and the expression (50 mg/kg) of CPP and CPA without affecting spatial memory (50 mg/kg), as determined by a two-trial memory recognition task. Overall, the study highlights the ability of WSE to interfere with both positive and negative motivational properties of ethanol and suggests that the effects of WSE may target both ethanol's motivational properties and underpinning associative learning mechanisms. In conclusion, these results cast new light on Withania somnifera as an agent potentially useful to counteract distinct aspects of ethanol effects.</p>},
  author       = {Spina, Liliana and Longoni, Rosanna and Rosas, Michela and Collu, Maria and Peana, Alessandra T and Espa, Elena and Kasture, Sanjay and Cotti, Elisabetta and Acquas, Elio},
  issn         = {1461-7285},
  keyword      = {Animals,Avoidance Learning,Conditioning (Psychology),Dose-Response Relationship, Drug,Ethanol,Male,Methanol,Mice,Plant Extracts,Plant Roots,Recognition (Psychology),Reward,Self Administration,Withania,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {11},
  pages        = {9--1191},
  publisher    = {SAGE Publications Inc.},
  series       = {Journal of Psychopharmacology},
  title        = {Withania somnifera Dunal (Indian ginseng) impairs acquisition and expression of ethanol-elicited conditioned place preference and conditioned place aversion},
  url          = {http://dx.doi.org/10.1177/0269881115600132},
  volume       = {29},
  year         = {2015},
}