Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma
Hardell, Karin ; Carlberg, Michael ; Hardell, Lennart ; Bjornfoth, Helen ; Jogsten, Ingrid Ericson ; Eriksson, Mikael LU
; Van Bavel, Bert
and Lindstrom, Gunilla
(2009)
In Oncology Reports
21(6).
p.1567-1576
- Abstract
- Exposure to some pesticides and persistent organic pollutants (POPs) has been indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been associated with some subgroups of NHL. In a previous study we found an interaction between high concentrations of some POPs and titres of antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study we measured lipid adjusted plasma concentrations of 35 congeners of polychlorinated biphenyls (PCB). p,p'-dichlorodiphenyldichloroethyelene (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes (cis-heptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, trans-nonachlordane, cis-nonachlordane) and one polybrominated... (More)
- Exposure to some pesticides and persistent organic pollutants (POPs) has been indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been associated with some subgroups of NHL. In a previous study we found an interaction between high concentrations of some POPs and titres of antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study we measured lipid adjusted plasma concentrations of 35 congeners of polychlorinated biphenyls (PCB). p,p'-dichlorodiphenyldichloroethyelene (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes (cis-heptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, trans-nonachlordane, cis-nonachlordane) and one polybrominated diphenylether (PBDE) congener (no. 47) in 99 cases with NHL and 99 population based controls. Odds ratios (OR) for NHL were estimated. Sum of PCBs > median in the controls gave odds ratio (OR) 2.0, 95% confidence interval (CI) 0.99-3.9. High sum of chlordanes yielded OR 2.3, 95% CI 1.2-4.5. An interaction with EBV EA IgG was found. High sum of PCB gave OR 5.2, 95% CI 1.9-14 in the group with EA IgG > 40. Similarly HCB yielded OR 5.3, 95% CI 1.9-15, pp'-DDE gave OR 3.3, 95% CI 1.4-7.7 and sum of chlordanes yielded OR 6.8, 95% CI 2.3-20, whereas no association was found with PBDE. In summary this study confirmed an association between certain POPs and NHL with all interaction with titre of IgG antibody to EBV EA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1425563
- author
- Hardell, Karin
; Carlberg, Michael
; Hardell, Lennart
; Bjornfoth, Helen
; Jogsten, Ingrid Ericson
; Eriksson, Mikael
LU
; Van Bavel, Bert
and Lindstrom, Gunilla
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pollutants, persistent organic, non-Hodgkin lymphoma, polychlorinated biphenyls, Epstein-Barr virus, aetiology
- in
- Oncology Reports
- volume
- 21
- issue
- 6
- pages
- 1567 - 1576
- publisher
- Spandidos Publications
- external identifiers
-
- wos:000266185900029
- scopus:67649987698
- ISSN
- 1791-2431
- DOI
- 10.3892/or_00000389
- language
- English
- LU publication?
- yes
- id
- bd654683-c9d9-46e0-9ce4-7c256b580690 (old id 1425563)
- date added to LUP
- 2016-04-01 14:19:22
- date last changed
- 2022-01-28 00:01:57
@article{bd654683-c9d9-46e0-9ce4-7c256b580690,
abstract = {{Exposure to some pesticides and persistent organic pollutants (POPs) has been indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been associated with some subgroups of NHL. In a previous study we found an interaction between high concentrations of some POPs and titres of antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study we measured lipid adjusted plasma concentrations of 35 congeners of polychlorinated biphenyls (PCB). p,p'-dichlorodiphenyldichloroethyelene (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes (cis-heptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, trans-nonachlordane, cis-nonachlordane) and one polybrominated diphenylether (PBDE) congener (no. 47) in 99 cases with NHL and 99 population based controls. Odds ratios (OR) for NHL were estimated. Sum of PCBs > median in the controls gave odds ratio (OR) 2.0, 95% confidence interval (CI) 0.99-3.9. High sum of chlordanes yielded OR 2.3, 95% CI 1.2-4.5. An interaction with EBV EA IgG was found. High sum of PCB gave OR 5.2, 95% CI 1.9-14 in the group with EA IgG > 40. Similarly HCB yielded OR 5.3, 95% CI 1.9-15, pp'-DDE gave OR 3.3, 95% CI 1.4-7.7 and sum of chlordanes yielded OR 6.8, 95% CI 2.3-20, whereas no association was found with PBDE. In summary this study confirmed an association between certain POPs and NHL with all interaction with titre of IgG antibody to EBV EA.}},
author = {{Hardell, Karin and Carlberg, Michael and Hardell, Lennart and Bjornfoth, Helen and Jogsten, Ingrid Ericson and Eriksson, Mikael and Van Bavel, Bert and Lindstrom, Gunilla}},
issn = {{1791-2431}},
keywords = {{pollutants; persistent organic; non-Hodgkin lymphoma; polychlorinated biphenyls; Epstein-Barr virus; aetiology}},
language = {{eng}},
number = {{6}},
pages = {{1567--1576}},
publisher = {{Spandidos Publications}},
series = {{Oncology Reports}},
title = {{Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma}},
url = {{http://dx.doi.org/10.3892/or_00000389}},
doi = {{10.3892/or_00000389}},
volume = {{21}},
year = {{2009}},
}