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Does Estimated Pulse Wave Velocity Add Prognostic Information? : MORGAM Prospective Cohort Project

Vishram-Nielsen, Julie K.K. ; Laurent, Stephane ; Nilsson, Peter M. LU ; Linneberg, Allan ; Sehested, Thomas S.G. ; Greve, Sara V. ; Pareek, Manan ; Palmieri, Luigi ; Giampaoli, Simona and Donfrancesco, Chiara , et al. (2020) In Hypertension 75(6). p.1420-1428
Abstract

The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) and Framingham Risk Score. The study aim was to investigate the independent association between ePWV and clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 to 97 years from the MORGAM Project who were included between 1982 and 2002 in 38 cohorts from 11 countries. Using multiple Cox-regression analyses, the predictive value of ePWV was calculated adjusting for country of inclusion and either SCORE, Framingham Risk Score, or traditional cardiovascular risk... (More)

The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) and Framingham Risk Score. The study aim was to investigate the independent association between ePWV and clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 to 97 years from the MORGAM Project who were included between 1982 and 2002 in 38 cohorts from 11 countries. Using multiple Cox-regression analyses, the predictive value of ePWV was calculated adjusting for country of inclusion and either SCORE, Framingham Risk Score, or traditional cardiovascular risk factors (age, sex, smoking, systolic blood pressure, body mass index [BMI], total and high-density lipoprotein cholesterol). Cardiovascular mortality consisted of fatal stroke, fatal myocardial infarction, or coronary death, and the composite cardiovascular end point consisted of stroke, myocardial infarction, or coronary death. Model discrimination was assessed using Harrell's C-statistic. Adjusting for country and logSCORE or Framingham Risk Score, ePWV was associated with all-cause mortality (hazard ratio, 1.23 [95% CI 1.20-1.25] per m/s or 1.32 [1.29-1.34]), cardiovascular mortality (1.26 [1.21-1.32] or 1.35 [1.31-1.40]), and composite cardiovascular end point (1.19 [1.16-1.22] or 1.23 [1.20-1.25]; all P<0.001). However, after adjusting for traditional cardiovascular risk factors, ePWV was only associated with all-cause mortality (1.15 [1.08-1.22], P<0.001) and not with cardiovascular mortality (0.97 [0.91-1.03]) nor composite cardiovascular end point (1.10 [0.97-1.26]). The areas under the last 3 receiver operator characteristic curves remained unchanged when adding ePWV. Elevated ePWV was associated with subsequent mortality and cardiovascular morbidity independently of systematic coronary risk evaluation and Framingham Risk Score but not independently of traditional cardiovascular risk factors.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular risk, prognosis, pulse wave velocity, reclassification
in
Hypertension
volume
75
issue
6
pages
9 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85084693375
  • pmid:32275189
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.119.14088
language
English
LU publication?
no
id
bd76f6e6-e74f-40ab-95e8-80e171887943
date added to LUP
2020-06-02 15:40:06
date last changed
2021-03-31 01:28:37
@article{bd76f6e6-e74f-40ab-95e8-80e171887943,
  abstract     = {<p>The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) and Framingham Risk Score. The study aim was to investigate the independent association between ePWV and clinical outcomes in 107 599 apparently healthy subjects (53% men) aged 19 to 97 years from the MORGAM Project who were included between 1982 and 2002 in 38 cohorts from 11 countries. Using multiple Cox-regression analyses, the predictive value of ePWV was calculated adjusting for country of inclusion and either SCORE, Framingham Risk Score, or traditional cardiovascular risk factors (age, sex, smoking, systolic blood pressure, body mass index [BMI], total and high-density lipoprotein cholesterol). Cardiovascular mortality consisted of fatal stroke, fatal myocardial infarction, or coronary death, and the composite cardiovascular end point consisted of stroke, myocardial infarction, or coronary death. Model discrimination was assessed using Harrell's C-statistic. Adjusting for country and logSCORE or Framingham Risk Score, ePWV was associated with all-cause mortality (hazard ratio, 1.23 [95% CI 1.20-1.25] per m/s or 1.32 [1.29-1.34]), cardiovascular mortality (1.26 [1.21-1.32] or 1.35 [1.31-1.40]), and composite cardiovascular end point (1.19 [1.16-1.22] or 1.23 [1.20-1.25]; all P&lt;0.001). However, after adjusting for traditional cardiovascular risk factors, ePWV was only associated with all-cause mortality (1.15 [1.08-1.22], P&lt;0.001) and not with cardiovascular mortality (0.97 [0.91-1.03]) nor composite cardiovascular end point (1.10 [0.97-1.26]). The areas under the last 3 receiver operator characteristic curves remained unchanged when adding ePWV. Elevated ePWV was associated with subsequent mortality and cardiovascular morbidity independently of systematic coronary risk evaluation and Framingham Risk Score but not independently of traditional cardiovascular risk factors.</p>},
  author       = {Vishram-Nielsen, Julie K.K. and Laurent, Stephane and Nilsson, Peter M. and Linneberg, Allan and Sehested, Thomas S.G. and Greve, Sara V. and Pareek, Manan and Palmieri, Luigi and Giampaoli, Simona and Donfrancesco, Chiara and Kee, Frank and Mancia, Giuseppe and Cesana, Giancarlo and Veronesi, Giovanni and Kuulasmaa, Kari and Salomaa, Veikko and Kontto, Jukka and Palosaari, Tarja and Sans, Susana and Ferrieres, Jean and Dallongeville, Jean and Söderberg, Stefan and Moitry, Marie and Drygas, Wojciech and Tamosiunas, Abdonas and Peters, Annette and Brenner, Hermann and Njolstad, Inger and Olsen, Michael H.},
  issn         = {0194-911X},
  language     = {eng},
  number       = {6},
  pages        = {1420--1428},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Hypertension},
  title        = {Does Estimated Pulse Wave Velocity Add Prognostic Information? : MORGAM Prospective Cohort Project},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14088},
  doi          = {10.1161/HYPERTENSIONAHA.119.14088},
  volume       = {75},
  year         = {2020},
}